230302-45-1Relevant academic research and scientific papers
Synthesis of the four diastereoisomers of the N-terminal amino acids of nikkomycins via aminoalkylation with preformed ternary iminium salts
Delbos-Krampe, Jeanne,Risch, Nikolaus,Fl?rke, Ulrich
, p. 414 - 423 (2004)
An efficient and convenient two step synthesis of each of the four possible diastereoisomers of the N-terminal amino acid component of nikkomycins is described. We first synthesized α-amino-β-oxo acids by aminoalkylation of ketones with iminium salts. The second step using Pearlman's catalyst gave directly nonnatural and natural precursors 13-16 of nikkomycins 1 which were easily separated by chromatography on silica gel.
ALDOSTERONE SYNTHASE AND/OR 11β-HYDROXYLASE INHIBITORS
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Page/Page column 50-51, (2008/06/13)
The present invention provides a compound of formula (I). Said compound is inhibitor of CYP11B2 and/or CYP11B1, and thus can be employed for the treatment of a disorder or disease mediated by CYP11B2 and/or CYP11B1.
Efficient synthesis of racemic α-aryl-α-amino acid esters via aminoalkylation with in situ generated glycine cation equivalents
Grumbach, Hans-Joachim,Merla, Beatrix,Risch, Nikolaus
, p. 1027 - 1033 (2007/10/03)
Iminium salts generated in situ from ethyl glyoxylate, secondary amines and 1-H-benzotriazole are demonstrated to be excellent reagents for the regioselective mono-aminoalkylation of indoles, phenols, furans and pyrroles. This method provides a simple and
