23039-94-3

Usage

Uses

Used in Pharmaceutical Synthesis:
TRIS(3-FLUOROPHENYL)PHOSPHINE is used as a catalyst in the synthesis of pharmaceuticals for its ability to facilitate various chemical reactions, including hydrogenation, isomerization, and cross-coupling reactions. Its reactivity and selectivity make it a valuable reagent in the production of complex organic molecules required for medicinal compounds.
Used in Agrochemical Production:
In the agrochemical industry, TRIS(3-FLUOROPHENYL)PHOSPHINE is utilized as a catalyst to enhance the synthesis of active ingredients for pesticides and other agricultural chemicals. Its role in these reactions helps to improve the efficiency and selectivity of the production process, leading to more effective and targeted agrochemicals.
Used in Fine Chemicals Manufacturing:
TRIS(3-FLUOROPHENYL)PHOSPHINE is employed as a key component in the production of fine chemicals, where its catalytic properties are harnessed to achieve high levels of reaction control and product purity. This is particularly important in applications requiring high-quality and specialized chemical intermediates.
Overall, TRIS(3-FLUOROPHENYL)PHOSPHINE's versatility in catalysis and its sensitivity to air and moisture highlight its importance in the fields of pharmaceuticals, agrochemicals, and fine chemicals manufacturing, where its unique properties contribute to the development of more effective and sophisticated chemical products.

InChI:InChI=1/C18H12F3P/c19-13-4-1-7-16(10-13)22(17-8-2-5-14(20)11-17)18-9-3-6-15(21)12-18/h1-12H

Upstream product

• 1073-06-9 3-fluorobromobenzene 

Downstream Products

• 52151-05-0 (CO)3NiP(C₆H₄F-m)3 
• 31237-96-4 cis-dichlorobis{tris(3-fluorophenyl)phosphane}platinum(II) 
• 872318-96-2 [(acetyl)(tris(m-fluorophenyl)phosphine)Co(CO)3] 
• 1268604-28-9 Ru₃(CO)9(tris(m-fluorophenyl)phosphine)3 
• 1268604-27-8 Ru₃(CO)11(tris(m-fluorophenyl)phosphine) 

Relevant academic research and scientific papers

Effects of phosphorus substituents on reactions of α- alkoxyphosphonium salts with nucleophiles

The effects of phosphorus substituents on the reactivity of α-alkoxyphosphonium salts with nucleophiles has been explored. Reactions of α-alkoxyphosphonium salts, prepared from various acetals and tris(o-tolyl)phosphine, with a variety of nucleophiles proceeded efficiently. These processes represent the first examples of high-yielding nucleophilic substitution reactions of α-alkoxyphosphonium salts. The reactivity of these salts was determined by a balance between steric and electronic factors, respectively, represented by cone angles θ and CO stretching frequencies ν (steric and electronic parameters, respectively). In addition, a novel reaction of α-alkoxyphosphonium salts derived from Ph3P with Grignard reagents was observed to take place in the presence of O2 to afford alcohols in good yields. A radical mechanism is proposed for this process that has gained support from isotope-labeling and radical-inhibition experiments. A dramatic change in the reactivity of an α-alkoxyphosphonium salt toward nucleophiles is observed due to the steric and electronic nature of the phosphine substituents. By changing the type of phosphorus substituents, the reaction pathway can be controlled to proceed selectively by substitution or a new radical reaction (see scheme; OTf=trifluoromethansulfonate, TMS=trimethylsilyl, o-tol=tolyl). Copyright

Syntheses and Spectroscopic Investigations of Substituted cis- and trans-Dichlorobis(triphenylphospane)platinum(II) Compounds

Compounds of the type cis- and trans-dichlorobis(triphenylphosphane)platinum(II) (3) with substituents of different electronic character in the phenyl rings bonded to phosphorus have been synthesized.The coupling constants 1J and the chloro-platinum valence vibrational frequencies are demonstrated to be criteria for unambiguous discrimination between cis- and trans-configurations at platinum; a linear correlation exists between the sum of the ?-constants of the sustituents at the triphenylphosphane and the coupling constants 1J.