23043-50-7Relevant academic research and scientific papers
Facile synthesis of unsymmetrical acridines and phenazines by a Rh(III)-catalyzed amination/cyclization/aromatization cascade
Lian, Yajing,Hummel, Joshua R.,Bergman, Robert G.,Ellman, Jonathan A.
supporting information, p. 12548 - 12551 (2013/09/23)
We report formal [3 + 3] annulations of aromatic azides with aromatic imines and azobenzenes to give acridines and phenazines, respectively. These transformations proceed through a cascade process of Rh(III)-catalyzed amination followed by intramolecular electrophilic aromatic substitution and aromatization. Acridines can be directly prepared from aromatic aldehydes by in situ imine formation using catalytic benzylamine.
