2305-31-9

Usage

Uses

Used in Chemical Synthesis:
Cis-1,3-cyclohexanedicarboxylic acid is used as a building block for the synthesis of other organic compounds. Its carboxylic acid groups facilitate the formation of esters, amides, and other derivatives, making it a versatile starting material in organic chemistry.
Used in Polymer Production:
cis-1,3-cyclohexanedicarboxylic acid is used as a monomer in the production of polymers. The presence of two carboxylic acid groups allows for the formation of polyesters and other polymers through condensation reactions, contributing to the development of new materials with specific properties.
Used in Biochemical Research:
Cis-1,3-cyclohexanedicarboxylic acid is used as a reagent in biochemical research. Its unique structure and functional groups make it a valuable tool for studying enzyme reactions, metabolic pathways, and other biological processes.
Used in Pharmaceutical Industry:
Cis-1,3-cyclohexanedicarboxylic acid is used as an intermediate in the synthesis of pharmaceutical compounds. Its chemical properties enable the creation of drug molecules with potential therapeutic applications.
Used in Material Science:
cis-1,3-cyclohexanedicarboxylic acid is used in the development of new materials with specific properties, such as improved strength, flexibility, or thermal stability. Its role in the synthesis of polymers and other compounds makes it an important component in material science research and development.

InChI:InChI=1/C8H12O4/c9-7(10)5-2-1-3-6(4-5)8(11)12/h5-6H,1-4H2,(H,9,10)(H,11,12)/t5-,6+

Upstream product

• 1459-93-4 dimethyl Isophthalate 
• 22605-65-8 cis-1,3-cyclohexanedicarbonyl chloride 
• 98558-90-8 6,6-Dihydroxy-bicyclo-<1.1.3>-heptan-carbonsaeure-(1) 
• 101499-78-9 Bicyclo-<1.1.3>-heptanon-(6)-yl-(1)-ester der 6.6-Dihydroxy-bicyclo-<1.1.3>-heptan-carbonsaeure-(1) 
• 121-91-5 isophthalic acid 
• 4355-31-1 3-oxabicyclo<3.3.1>nonane-2,4-dione 
• 626-15-3 1,3-bis-(bromomethyl)benzene 
• 1610728-91-0 (S,S)-dibenzyl cyclohexyl 1,3-dicarboxylate 
• 110333-10-3 C₁₀H₁₂O₄ 
• 98490-87-0 Bicyclo-<1.1.3>-heptanon-(6)-carbonsaeure-(1)-chlorid 
• 100378-67-4 Bicyclo-<1.1.3>-heptanon-(6)-carbonsaeure-(1) 
• 1165952-92-0 cyclohexa-1,4-diene 
• 109559-41-3 1,1,3,3-tetraethoxycarbonylcyclohexane 
• 77976-01-3 2,4-dimethoxybicyclo<3.3.1>nona-9-one 

Downstream Products

• 6998-82-9 dimethyl cis-1,3-cyclohexanedicarboxylate 
• 5059-76-7 ((1R,3S)-cyclohexane-1,3-diyl)dimethanol 
• 157888-10-3 cis-1,3-bis[(trifluoromethylsulfonyloxy)-methyl]cyclohexane 
• 455333-20-7 cis-1,3-bis[(diphenylphosphanyl)methyl]cyclohexane 
• 3540-83-8 3-Methyl-3-aza-bicyclo<3.3.1>nonan-methoiodid 
• 1610729-37-7 N-(5-((1S,3S)-3-(5-amino-1,3,4-thiadiazol-2-yl)cyclohexyl)-1,3,4-thiadiazol-2-yl)-2-(pyridin-2-yl)acetamide 

Relevant academic research and scientific papers

Search for a predicted hydrogen bonding motif - A multidisciplinary investigation into the polymorphism of 3-azabicyclo[3.3.1]nonane-2,4-dione

The predictions of the crystal structure of 3-azabicyclo[3.3.1]nonane-2,4- dione submitted in the 2001 international blind test of crystal structure prediction (CSP2001) led to the conclusion that crystal structures containing an alternative hydrogen bond

Highly-efficient Ru/Al-SBA-15 catalysts with strong Lewis acid sites for the water-assisted hydrogenation of: P -phthalic acid

Ruthenium nanoparticles supported onto aluminum-doped mesoporous silica catalysts (Ru/Al-SBA-15) are fabricated using hydrothermal and impregnation methods for catalysis application. The Ru/Al-SBA-15-3 catalyst at a Si/Al molar ratio of 3 exhibited excellent catalytic performance for the hydrogenation of p-phthalic acid with high conversion efficiency (100.0%) and cis-isomer selectivity (84.0%) in water. Moreover, this system displays exceptional stability and recyclability through preserving the conversion efficiency, as well as a cis-isomer selectivity of 90.2 and 83.3%, respectively, after reusing it fourteen times. Such an exceptional system can also be ideal for the hydrogenation of aromatic dicarboxylic acids and their ester derivatives in water. Strong Lewis acid sites due to doped Al species play significant roles in the hydrogenation reaction. Moreover, isotope labeling studies indicated that water molecules effectively participated in the hydrogenation reaction. Hydrogen and water contributed half of the hydrogen atoms for this hydrogenation reaction. In the end, a plausible mechanistic pathway for the hydrogenation of p-phthalic acid using the Ru/Al-SBA-15-3 catalyst in water is proposed.

COMPOUNDS AND THEIR METHODS OF USE

Compounds and compositions comprising compounds that inhibit glutaminase are described herein. Also described herein are methods of using the compounds that inhibit glutaminase in the treatment of cancer.

COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND USES AS GLUTAMINASE INHIBITORS FOR TREATING CANCERS THEREOF

Provided are compounds of formula (I), wherein X, Y, Z, W, m, n, o, p, R1, R2 and R6 are defined as in the description. Pharmaceutical compositions and uses as glutaminase inhibitors for treating cancers thereof are also provided.

COMPOUNDS AND THEIR METHODS OF USE

Provided are compounds of formula (I), which can inhibit glutaminase. Pharmaceutical compositions comprising these compounds and uses as glutaminase inhibitors for treating cancers thereof are also provided.

Efficient and Practical Arene Hydrogenation by Heterogeneous Catalysts under Mild Conditions

An efficient and practical arene hydrogenation procedure based on the use of heterogeneous platinum group catalysts has been developed. Rh/C is the most effective catalyst for the hydrogenation of the aromatic ring, which can be conducted in iPrOH under neutral conditions and at ordinary to medium H 2 pressures (10 atm). A variety of arenes such as alkylbenzenes, benzoic acids, pyridines, furans, are hydrogenated to the corresponding cyclohexyl and heterocyclic compounds in good to excellet yields. The use of Ru/C, less expensive than Rh/C, affords an effective and practical method for the hydrogenation of arenes including phenols. Both catalysts can be reused several times after simple filtration without any significant loss of catalytic activity.

An Efficient and Practical Synthesis of Bicyclononane-2,4-diones

Cyclohexane-1,3-dicarboxylic anhydrides (IVa-c), prepared from isophthalic acids in several steps, were treated with diethyl magnesiomalonate and triethylamine to give 3-di(ethoxycarbonyl)acetylcyclohexanecarboxylic acids (Va-c) in good yields.Compounds V

1,1-Alkanediol dicarboxylate linked antibacterial agents

Useful antibacterial agents in which a penicillin and/or a beta-lactamase inhibitor are linked via 1,1-alkanediol dicarboxylates are of the formula STR1 where A is the residue of certain dicarboxyic acids, R3 is H or (C1 -C3), n is zero or 1 such that when n is zero R is P or B and R1 is the residue of certain esters, H or a salt thereof; and when n is 1, one of R and R1 is P and the other is B, and P is STR2 where R2 is H or certain acyl groups, and B is the residue of a beta-lactamase inhibiting carboxylic acid; a method for their use, pharmaceutical compositions thereof and intermediates useful in their production.

The 1,3-dimethoxytrimethylene bridge as two latent carboxyl groups: synthesis of cis-isoaposantenic and cis-apocamphoric acids

The syntheses of cis-cyclopentane-1,3-dicarboxylic acid, cis-cyclohexane-1,3-dicarboxylic acid, cis-isoaposantenic acid, and cis-apochamphoric acid are described.The key step of each synthesis is the bromine oxidation of an appropiate bicyclic compound in which a 1,3-dimethoxytrimethylene bridge is converted into two cis-carboxyl groups.