5059-76-7Relevant academic research and scientific papers
Production of Copolyester Monomers from Plant-Based Acrylate and Acetaldehyde
Yuan, Lin,Hu, Yancheng,Zhao, Zhitong,Li, Guangyi,Wang, Aiqin,Cong, Yu,Wang, Feng,Zhang, Tao,Li, Ning
supporting information, (2021/12/14)
PCTA is an important copolyester that has been widely used in our daily necessities. Currently, its monomers are industrially produced from petroleum-derived xylene. To reduce the reliance on fossil energy, we herein disclose an alternative route to acces
Stereoselective synthesis of alicyclic ketones: A hydrogen borrowing approach
Armstrong, Roly J.,Akhtar, Wasim M.,Frost, James R.,Christensen, Kirsten E.,Stevenson, Neil G.,Donohoe, Timothy J.
supporting information, (2019/11/13)
A highly diastereoselective annulation strategy for the synthesis of alicyclic ketones from diols and pentamethylacetophenone is described. This process is mediated by a commercially available iridium(III) catalyst, and provides efficient access to a wide range of cyclopentane and cyclohexane products with high levels of stereoselectivity. The origins of diastereoselectivity in the annulation reaction have been explored by a series of control experiments, which provides an explanation for how each stereocentre around the newly forged ring is controlled.
GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE
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Paragraph 001540; 001541; 00154; 002261; 002262; 002264, (2019/07/17)
Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with the enzyme glycolate oxidase (GO). Such diseases or disorders include, for example, disorders of glyoxylate metabolism, including primary hyperoxaluria, that are associated with production of excessive amounts of oxalate.
BIPOLAR TETRAETHER LIPIDS
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, (2017/03/21)
Disclosed herein, inter alia, are compounds, compositions, and liposomes and methods of thereof.
Cyclohexane Rings Reduce Membrane Permeability to Small Ions in Archaea-Inspired Tetraether Lipids
Koyanagi, Takaoki,Leriche, Geoffray,Onofrei, David,Holland, Gregory P.,Mayer, Michael,Yang, Jerry
, p. 1890 - 1893 (2016/02/03)
Extremophile archaeal organisms overcome problems of membrane permeability by producing lipids with structural elements that putatively improve membrane integrity compared to lipids from other life forms. Herein, we describe a series of lipids that mimic some key structural features of archaeal lipids, such as: 1) single tethering of lipid tails to create fully transmembrane tetraether lipids and 2) the incorporation of small rings into these tethered segments. We found that membranes formed from pure tetraether lipids leaked small ions at a rate that was about two orders of magnitude slower than common bilayer-forming lipids. Incorporation of cyclopentane rings into the tetraether lipids did not affect membrane leakage, whereas a cyclohexane ring reduced leakage by an additional 40 %. These results show that mimicking certain structural features of natural archaeal lipids results in improved membrane integrity, which may help overcome limitations of many current lipid-based technologies.
Catalytic dehydrogenation of cyclooctane and triethylamine using aliphatic iridium pincer complexes Dedicated to John Bercaw on the occasion of his 70th birthday
Polukeev, Alexey V.,Gritcenko, Roman,Jonasson, Klara J.,Wendt, Ola F.
, p. 63 - 66 (2015/02/19)
The majority of the known pincer iridium based catalysts for dehydrogenation of alkanes has arene-based backbones. Here, the catalytic activity of aliphatic iridium pincer complexes, viz. the cyclohexane-based phosphine complex (PCyP)IrHCl (4) (PCyP = {cis-1,3-bis-[(di-tert-butylphosphino)methyl]cyclohexane}-) and the 2-methylpropane-based phosphinite complex (POCOP)IrHCl (5) (POCOP = 1,3-bis-(di-tert-butylphosphinito)-2-methylpropane-), in dehydrogenation of cyclooctane and triethylamine was studied. They give TONs that are in the range of 0-200. In addition, improved procedures for synthesis and metallation of the PCyP ligand (3) are presented.
A new highly active diphosphane-palladium(II) complex as a catalyst precursor for the heck reaction
Sjoevall, Sven,Johansson, Maria H.,Andersson, Carlaxel
, p. 2907 - 2912 (2007/10/03)
The new diphosphane ligand cis-1,3-bis[(diphenylphosphanyl)methyl]cyclohexane (4) has been prepared and has allowed the synthesis of the palladium complex cis-[Pd(4)(CO2CF3)2] (6). To obtain cis complexation of the diphosp
Bioactive hydroxyethylene dipeptide isosteres with hydrophobic (P3- P1)-moieties. A novel strategy towards small non-peptide renin inhibitors
Rasetti, Vittorio,Cohen, N. Claude,Rueeger, Heinrich,Goeschke, Richard,Maibaum, Juergen,Cumin, Frederic,Fuhrer, Walter,Wood, Jeanette M.
, p. 1589 - 1594 (2007/10/03)
The design and synthesis of new truncated δ-amino hydroxyethylene dipeptide isosteres lacking the P4-P2 peptide backbone is described. The most active compounds 15c and 30c inhibited human renin in the submicromolar range. This promising concept may offer the possibility to discover completely non-peptide, low-molecular weight renin inhibitors with improved pharmacokinetic properties.
