5059-76-7

Usage

Uses

Used in Chemical Synthesis Industry:
((1R,3S)-cyclohexane-1,3-diyl)dimethanol is used as a building block for the synthesis of polymers, resins, and other organic compounds. Its unique cyclohexane ring structure and specific stereochemistry make it a valuable component in creating materials with tailored chemical and physical properties.
Used in Research Applications:
((1R,3S)-cyclohexane-1,3-diyl)dimethanol is utilized in research settings for the development and study of new materials and compounds. Its distinct spatial arrangement of hydroxyl groups allows for the exploration of novel chemical reactions and the creation of innovative products with specific properties.

Upstream product

• 6998-82-9 dimethyl cis-1,3-cyclohexanedicarboxylate 
• 6896-46-4 3-propyl-3-bora-bicyclo[3.3.1]nonane 
• 88211-29-4 cis-1,3-bis((benzyloxy)methyl)cyclohexane 
• 2305-31-9 cis-cyclohexane-1,3-dicarboxylic acid 
• 88211-20-5 (+/-)-cis-1-bromo-3,5-bis(hydroxymethyl)cyclohexene 
• 88211-26-1 (+/-)-cis-1-bromo-3,5-bis((benzyloxy)methyl)cyclohexene 
• 88211-21-6 cis-3,5-bis((benzyloxy)methyl)cyclohexanone 
• 88211-28-3 (7R,9S)-7,9-Bis-benzyloxymethyl-1,4-dithia-spiro[4.5]decane 
• 88211-27-2 (+/-)-cis-1-acetoxy-3,5-bis((benzyloxy)methyl)cyclohexene 
• 636-53-3 diethyl isophthalate 
• 98837-34-4 ethyl 3-hydroxy-2-methylenebutanoate 
• 140-88-5 ethyl acrylate 
• 10021-92-8 dimethyl cyclohexane-trans-1,3-dicarboxylate 
• 116724-13-1 trans rac-cyclohexyl 1,3-dicarboxylic acid 

Downstream Products

• 313361-18-1 cis-1,3-bis-methanesulfonyloxymethyl-cyclohexane 
• 111162-61-9 cis-1,3-bis-(toluene-4-sulfonyloxymethyl)-cyclohexane 
• 65376-02-5 (1S,6R)-8-oxabicyclo[4.3.0]nonan-7-one 
• 89395-29-9 (3aR,7aS)-hexahydroisobenzofuran-1-one 
• 10036-09-6 bicyclo[3.3.1]nonan-3-one 
• 3971-28-6 (-)-trans-1,3-bis-hydroxymethyl-cyclohexane 
• 111162-61-9 (-)-trans-1,3-bis-(toluene-4-sulfonyloxymethyl)-cyclohexane 

Relevant academic research and scientific papers

Production of Copolyester Monomers from Plant-Based Acrylate and Acetaldehyde

PCTA is an important copolyester that has been widely used in our daily necessities. Currently, its monomers are industrially produced from petroleum-derived xylene. To reduce the reliance on fossil energy, we herein disclose an alternative route to acces

Stereoselective synthesis of alicyclic ketones: A hydrogen borrowing approach

A highly diastereoselective annulation strategy for the synthesis of alicyclic ketones from diols and pentamethylacetophenone is described. This process is mediated by a commercially available iridium(III) catalyst, and provides efficient access to a wide range of cyclopentane and cyclohexane products with high levels of stereoselectivity. The origins of diastereoselectivity in the annulation reaction have been explored by a series of control experiments, which provides an explanation for how each stereocentre around the newly forged ring is controlled.

GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE

Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with the enzyme glycolate oxidase (GO). Such diseases or disorders include, for example, disorders of glyoxylate metabolism, including primary hyperoxaluria, that are associated with production of excessive amounts of oxalate.

BIPOLAR TETRAETHER LIPIDS

Disclosed herein, inter alia, are compounds, compositions, and liposomes and methods of thereof.

Cyclohexane Rings Reduce Membrane Permeability to Small Ions in Archaea-Inspired Tetraether Lipids

Extremophile archaeal organisms overcome problems of membrane permeability by producing lipids with structural elements that putatively improve membrane integrity compared to lipids from other life forms. Herein, we describe a series of lipids that mimic some key structural features of archaeal lipids, such as: 1) single tethering of lipid tails to create fully transmembrane tetraether lipids and 2) the incorporation of small rings into these tethered segments. We found that membranes formed from pure tetraether lipids leaked small ions at a rate that was about two orders of magnitude slower than common bilayer-forming lipids. Incorporation of cyclopentane rings into the tetraether lipids did not affect membrane leakage, whereas a cyclohexane ring reduced leakage by an additional 40 %. These results show that mimicking certain structural features of natural archaeal lipids results in improved membrane integrity, which may help overcome limitations of many current lipid-based technologies.

Catalytic dehydrogenation of cyclooctane and triethylamine using aliphatic iridium pincer complexes Dedicated to John Bercaw on the occasion of his 70th birthday

The majority of the known pincer iridium based catalysts for dehydrogenation of alkanes has arene-based backbones. Here, the catalytic activity of aliphatic iridium pincer complexes, viz. the cyclohexane-based phosphine complex (PCyP)IrHCl (4) (PCyP = {cis-1,3-bis-[(di-tert-butylphosphino)methyl]cyclohexane}-) and the 2-methylpropane-based phosphinite complex (POCOP)IrHCl (5) (POCOP = 1,3-bis-(di-tert-butylphosphinito)-2-methylpropane-), in dehydrogenation of cyclooctane and triethylamine was studied. They give TONs that are in the range of 0-200. In addition, improved procedures for synthesis and metallation of the PCyP ligand (3) are presented.

A new highly active diphosphane-palladium(II) complex as a catalyst precursor for the heck reaction

The new diphosphane ligand cis-1,3-bis[(diphenylphosphanyl)methyl]cyclohexane (4) has been prepared and has allowed the synthesis of the palladium complex cis-[Pd(4)(CO2CF3)2] (6). To obtain cis complexation of the diphosp

Bioactive hydroxyethylene dipeptide isosteres with hydrophobic (P3- P1)-moieties. A novel strategy towards small non-peptide renin inhibitors

The design and synthesis of new truncated δ-amino hydroxyethylene dipeptide isosteres lacking the P4-P2 peptide backbone is described. The most active compounds 15c and 30c inhibited human renin in the submicromolar range. This promising concept may offer the possibility to discover completely non-peptide, low-molecular weight renin inhibitors with improved pharmacokinetic properties.