2305-54-6

Usage

Usage

Used in various industrial and research applications

Building block

Utilized in organic synthesis and production of pharmaceuticals, agrochemicals, and other chemical products

Reagent

Potential as a reagent in creating new materials and molecular structures

Pharmaceutical industry

Useful component for synthesis of potential drug candidates and biologically active compounds

Role in organic chemistry

Plays a significant role and has wide range of potential applications in various industries

Upstream product

• 62-53-3 aniline 
• 94-05-3 ethyl (ethoxymethylene)cyanoacetate 
• 1783-25-1 N₁,N₁-dimethyl-N₂-phenylformamidine 
• 105-56-6 ethyl 2-cyanoacetate 
• 122-51-0 orthoformic acid triethyl ester 
• 864131-95-3 N,N'-diphenylformamidine 

Downstream Products

• 59747-00-1 ethyl 3-((4-bromophenyl)amino)-2-cyanoacrylate 
• 19123-03-6 3-anilino-acrylic acid 
• 2305-70-6 4-hydroxyquinoline-3-carbonitrile 
• 1427690-28-5 diethyl 1-phenyl-3-((triphenylphosphoranylidene)amino)-1H-pyrrole-2,4-dicarboxylate 
• 1375969-42-8 ethyl 2-(diethylamino)-4-oxo-3,5-diphenyl-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidine-7-carboxylate 

Relevant academic research and scientific papers

Efficient and selective construction of pyrrolo[3,2-d]pyrimidine derivatives

An efficient and selective method for the synthesis of ethyl 2-amino/aryloxy-3-aryl-4-oxo-5-phenyl-4,5-dihydro-3H-pyrrolo[3,2-d] pyrimidine-7-carboxylate derivatives has been developed. The main process involved the reaction of diethyl 1-phenyl-3-((triphe

Highly efficient thermal cyclization reactions of alkylidene esters in continuous flow to give aromatic/heteroaromatic derivatives

Intramolecular thermal cyclization and benzannulation reactions of the Gould-Jacobs and Conrad-Limpach types were performed in a designed continuous flow reactor system at temperatures in the range of 300-360°C and under high pressure conditions (100-160 bar) with very short residence times (0.45-4.5 min) in tetrahydrofuran as a low-boiling point solvent. Substituted heteroaromatic compounds including pyridopyrimidinones and hydroxyquinolines were synthesized in moderate to high yields. Application of the reaction conditions also allows the synthesis of naphthol and biphenyl derivatives. The procedure involves an easy work-up and the non-batchwise preparative synthesis method is suitable for automation.

Microwave-assisted simple synthesis of substituted 4-quinolone derivatives

A simple and efficient method was developed for the synthesis of 4-quinolone-3-carboxylic esters and 4-quinolone-3-carbonitriles under microwave (MW) activation using anilines and acrylates as materials. All reactions demonstrated the benefits of microwave reactions: convenient operation, short reaction time, and good yields.

Solvent-free synthesis of quinolone derivatives

Quinolones can be prepared in a three step procedure from triethylorthoformate and activated methylene derivatives leading to alkoxymethylenemalonates followed by reaction with aromatic amines and finally a cyclization. All the reactions were carried out under solvent-free conditions possibly under microwave activation with benefits for the first step.

Derivatives of quinoline as alpha-2 antagonists

A compound of formula I, wherein A, Ra, Rb, R1 to R5, m and t are as defined as disclosed, or a pharmaceutically acceptable salt or ester thereof, useful as an alpha-2 antagonist. The compounds I can be used for the treatment of diseases or conditions where alpha-2 antagonists are indicated to be effective.