357425-93-5

Upstream product

• 104-15-4 toluene-4-sulfonic acid 
• 357426-13-2 1,5-methano-2-oxo-2,3,4,5-tetrahydro-1H-3-benzazepine 
• 230615-48-2 3-benzyl-2,3,4,5-tetrahydro-1,5-methano-1H-3-benzazepine 
• 357426-11-0 methyl 3-cyano-3-(trimethylsilanyloxy)indan-1-carboxylate 
• 29427-69-8 3-oxoindan-1-carboxylic acid 
• 29427-70-1 methyl 3-oxo-2,3-dihydro-1H-indene-1-carboxylate 
• 26326-70-5 (1R,2R,3S,4S)-1,2,3,4-tetrahydro-1,4-methanonaphthalene-2,3-diol 
• 542-92-7 cyclopenta-1,3-diene 
• 583-53-9 2,3-dibromobenzene 
• 2856-63-5 2-Chlorophenylacetonitrile 
• 19472-74-3 2-(2-bromophenyl)acetonitrile 
• 474024-38-9 3-[1,3]dioxolan-2-ylidene-3H-indene-1-carbonitrile 

Downstream Products

• 230615-51-7 1-(10-aza-tricyclo[6.3.1.0^2,7]dodeca-2⁽⁷⁾,3,5-trien-10-yl)-2,2,2-trifluoro-ethanone 

Relevant academic research and scientific papers

Preparation of 1,5-methano-2,3,4,5-tetrahydro-1H-3-benzazepine via Pd-catalyzed cyclization

(Equation Presented) A new approach to prepare 1,5-methano-2,3,4,5- tetrahydro-1H-3-benzanepine (1) is discussed. This strategy utilized a tandem Michael addition and Pd-catalyzed cyclization to afford cyanobenzofulvene acetal 13. This indene intermediate

Synthesis of 2,3,4,5-tetrahydro-1,5-methano-1H-3-benzazepine via oxidative cleavage and reductive amination strategies

Preparations of 2,3,4,5-tetrahydro-1,5-methano-1H-3-benzazepine (5) from benzonorbornadiene (1) by oxidative cleavage and reductive amination sequences were investigated. Osmium-mediated dihydroxylation of 1 followed by NaIO 4 cleavage, reductive amination and debenzylation provides 5 in 64-73% yield overall in three operations. A tandem ozonolysis-reductive amination procedure gives 5 as the tosylate salt from benzonorbornadiene with no isolation of intermediates in 28% yield.

A general route to the synthesis of 1,5-methano- and 1,5-ethano-2, 3,4,5-tetrahydro-1h-3-benzazepines

A general approach to preparing 1,5-methano-(1) and l,5-ethano-2,3,4,5- tetrahydro-lff-3-benzazepine (2) is discussed. This strategy involves converting an indanone or tetralone (4) to a cyanohydrin (3) which is subjected to hydrogenolysis followed by lac

Aryl fused azapolycyclic compounds

Compounds of the formula and their pharmaceutically acceptable salts, wherein R1, R2, and R3are as defined herein; intermediates for the synthesis of such compounds, pharmaceutical compositions containing such compounds; a

Process for the preparation of 1,3-substituted indenes and aryl-fused azapolycyclic componunds

The present invention relates to processes for the preparation of any of the intermediate 1,3-substituted indenes of the formulae (Ia), (Ib) and (Ic) or a mixture thereof: wherein R1, R2, R3, R4, and R5 are defined herein. Compounds of formulae (Ia), (Ib) and (IC) or mixtures thereof are useful in the preparation of compounds of formula (II): wherein R2, R3 and R6 are also defined herein.