230617-99-9

Upstream product

• 186021-07-8 (E)-17-bromo-4,7,10,13-tetraoxa-15-heptadecenoic acid phenacyl ester 
• 144564-94-3 N-((N-⁴-(benzyloxycarbonyl)cytosin-1-yl)acetyl)-N-(2-Boc-aminoethyl)glycine 

Downstream Products

• 230618-01-6 C₆₃H₇₀N₂₀O₁₉ 

Relevant academic research and scientific papers

Convergent strategies for the attachment of fluorescing reporter groups to peptide nucleic acids in solution and on solid phase

The site-selective conjugation of peptide nucleic acids (PNA) with fluorescent reporter groups is essential for the construction of hybridisation probes that can report the presence of a particular DNA sequence. This paper describes convergent methods for

Solid phase synthesis of protected peptide nucleic acids

Boc/Z-protected PNA oligomers were synthesised on solid phase. The use of the allylic HYCRON resin allowed for the application of both Boc- and Fmoc-protecting groups. Highest yields were obtained when the monomeric building block was synthesised on solid phase rather than loaded as preformed unit. The selective attachment of fluorescent labels at the C-terminal (3') end demonstrated for the first time that further manipulations on protected PNA fragments are feasible.