230643-51-3Relevant academic research and scientific papers
Process and chiral amine intermediates useful for preparation of antiproliferative 2,4-diaminothiazole amide compounds
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, (2008/06/13)
This invention relates to a novel process for preparing D-alanine derivatives and bis-toluenesulfonic acid salts thereof useful as intermediates in the preparation of 2,4-diaminothiazole amide compounds and pharmaceutical compositions containing such compounds. The invention also relates to such compounds and compositions that demonstrate antiproliferative activity such as antitumor activity. These compounds and compositions are also useful for treating various diseases and disorders associated with uncontrolled or unwanted cell proliferation and for inhibiting protein kinases.
Antiproliferative 2-(heteroaryl)-aminothiazole compounds and pharmaceutical compositions, and methods for their use
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Page/Page column 26, (2010/02/10)
Compounds represented by the Formula (I): are described. The compounds and pharmaceutical compositions containing them may be used in inhibiting and/or modulating protein kinases, in treating or preventing diseases associated with protein kinases, and/or in treating or preventing cellular proliferative diseases.
