486414-33-9

Upstream product

• 26607-51-2 N-benzyloxycarbonyl-D-alanine 
• 506-59-2 N,N-dimethylammonium chloride 
• 124-40-3 dimethyl amine 
• 689248-35-9 Dimethylcarbamoylmethyl-((2R,6R)-6-methyl-tetrahydro-pyran-2-yl)-carbamic acid benzyl ester 

Downstream Products

• 1422128-57-1 N²-[(5Z)-5-({1-[2,4-bis(trifluoromethyl)benzyl]piperidin-4-yl}methylidene)-2-oxo-2,5-dihydro-1,3-thiazol-4-yl]-N,N-dimethyl-D-alaninamide 
• 486414-34-0 (2-dimethylamino-1R-methyl-ethyl)-carbamic acid benzyl ester 
• 230643-51-3 (R)-2-amino-N,N-dimethylpropanamide 

Relevant academic research and scientific papers

NITROGEN-CONTAINING HETEROCYCLIC COMPOUND

The present invention provides a novel compound having a superior activity as an ERR-alpha modulator and useful as an agent for the prophylaxis or treatment of ERR-alpha associated diseases. The present invention relates to a compound represented by the formula (1) wherein each symbol is as defined in the specification, or a salt thereof

Antiproliferative 2-(heteroaryl)-aminothiazole compounds and pharmaceutical compositions, and methods for their use

Compounds represented by the Formula (I): are described. The compounds and pharmaceutical compositions containing them may be used in inhibiting and/or modulating protein kinases, in treating or preventing diseases associated with protein kinases, and/or in treating or preventing cellular proliferative diseases.

6-Methyl δ-lactol derived chiral glycine equivalents for the asymmetric synthesis of protected α-amino amides

Two new δ-lactol derived chiral glycine equivalents have been prepared in one-pot processes in good yields from the known 6- methyltetrahydropyran-2-ol. Alkylation proceeds in moderate to good yields and moderate to good selectivities under experimentally simple conditions. The lactol chiral auxiliary is readily removed under mild acidic conditions to give N-Cbz protected alpha-amino amides in good yields.

CamTHP*OH: A camphor-derived δ-lactol auxiliary for the effective desymmetrization of attached glycinamide residues. Asymmetric synthesis of α-amino carbonyl compounds

(Chemical equation presented) Stereoselective allylation of camphor and subsequent terminal hydroformylation affords a new δ-lactol auxiliary (camTHP*OH) on multigram scale. Stereoselective condensation with glycine dimethylamide and Cbz protection afford

Thiazole benzamide derivatives and pharmaceutical compositions for inhibiting cell proliferation, and methods for their use

Aminothiazole compounds with mono-/di-substituted benzamide are represented by the Formula (I), and their pharmaceutically acceptable salts, pharmaceutically acceptable prodrugs, pharmaceutically active metabolites, and pharmaceutically acceptable salts of said metabolites are described. These agents modulate and/or inhibit the cell proliferation and activity of protein kinases and are useful as pharmaceuticals for treating malignancies and other disorders.