23068-44-2

Usage

Chemical Properties

Clear colorless to faintly yellow liquid

InChI:InChI=1/C10H15N/c1-8-3-4-9(2)10(7-8)5-6-11/h3-4,7H,5-6,11H2,1-2H3/p+1

Upstream product

• 16213-85-7 (2,5-dimethylphenyl)acetonitrile 
• 2039-89-6 2,5-dimethylstyrene 
• 1056474-07-7 2-(2,5-dimethylphenyl)nitroethene 

Downstream Products

• 1041850-45-6 [2-(2,5-dimethylphenyl)ethyl]-{4-[4-(4-fluorophenyl)-2-methylsulfanyl-1H-imidazol-5-yl]pyridin-2-yl}amine 
• 160891-89-4 1-(2-methyl-6-nitrophenyl)-3,4-dihydro-5,8-dimethylisoquinoline 
• 160891-91-8 1-(2-methyl-6-nitrophenyl)-5,8-dimethylisoquinoline 
• 160891-87-2 N-(2-methyl-6-nitrobenzoyl)-2-(2,5-dimethylphenyl)ethylamine 

Relevant academic research and scientific papers

Direct Access to Primary Amines from Alkenes by Selective Metal-Free Hydroamination

Direct and selective synthesis of primary amines from easily available precursors is attractive yet challenging. Herein, we report the rapid synthesis of primary amines from alkenes via metal-free regioselective hydroamination at room temperature. Ammonium carbonate was used as ammonia surrogate for the first time, allowing for efficient conversion of terminal and internal alkenes into linear, α-branched, and α-tertiary primary amines under mild conditions. This method provides a straightforward and powerful approach to a wide spectrum of advanced, highly functionalized primary amines which are of particular interest in pharmaceutical chemistry and other areas.

Reductive cyclization of 1-(2-nitroaryl)isoquinoline derivatives

Isoquinoline derivatives 3b and 3c were prepared and their triethyl phosphite mediated reductive cyclization reactions investigated. Only the indazolo[3,2-a]isoquinolines 4b and 4c were formed.