23074-07-9

Basic information

• Product Name: 3-hydroxyglibenclamide
• Synonyms: 3-hydroxyglibenclamide
• CAS NO: 23074-07-9
• Molecular Formula: C23H28ClN3O6S
• Molecular Weight: 510.00292
• Mol File: 23074-07-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.41g/cm³
• Refractive Index: 1.63
• CAS DataBase Reference: 3-hydroxyglibenclamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxyglibenclamide(23074-07-9)
• EPA Substance Registry System: 3-hydroxyglibenclamide(23074-07-9)

Safety Data

• Hazardous Substances Data: 23074-07-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C23H28ClN3O6S/c1-33-21-10-7-16(24)13-20(21)22(29)25-12-11-15-5-8-19(9-6-15)34(31,32)27-23(30)26-17-3-2-4-18(28)14-17/h5-10,13,17-18,28H,2-4,11-12,14H2,1H3,(H,25,29)(H2,26,27,30)

Upstream product

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Relevant articles and documents

Hydroxyl-Substituted sulfonylureas as potent inhibitors of specific [3H]Glyburide binding to rat brain synaptosomes

We are seeking to discover potent CNS-active sulfonylureas with structural features that allow for the formation of several types of prodrugs. We report herein the syntheses of compounds comprising an initial series of hydroxyl-substituted analogues of the potent ATP-sensitive potassium channel blockers glyburide (glibenclamide) and gliquidone. Somewhat unexpectedly, several of the compounds were found to be comparably potent to glyburide as inhibitors of specific [3H]glyburide binding in rat brain preparations.