14511-59-2 Usage
Uses
Used in Pharmaceutical Industry:
Ethyl 4-[2-(5-Chloro-2-methoxybenzamido)ethyl]benzene Sulfonamide Carbamate is used as an impurity in the synthesis of Glyburide (G598350) for the development of pharmaceutical products. Its presence in the synthesis process may affect the purity and efficacy of the final product, making it an important consideration in the manufacturing process.
Used in Chemical Research:
As a complex organic compound, Ethyl 4-[2-(5-Chloro-2-methoxybenzamido)ethyl]benzene Sulfonamide Carbamate may also be used in chemical research for studying its properties, potential reactions, and possible applications in various fields. Researchers may explore its chemical behavior, stability, and interactions with other compounds to better understand its potential uses and limitations.
Used in Quality Control and Analysis:
The identification of Ethyl 4-[2-(5-Chloro-2-methoxybenzamido)ethyl]benzene Sulfonamide Carbamate as an impurity in the synthesis of Glyburide (G598350) highlights its importance in quality control and analysis within the pharmaceutical industry. It may be used as a reference compound for testing and validating analytical methods, ensuring the purity and safety of the final product.
Check Digit Verification of cas no
The CAS Registry Mumber 14511-59-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,5,1 and 1 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 14511-59:
(7*1)+(6*4)+(5*5)+(4*1)+(3*1)+(2*5)+(1*9)=82
82 % 10 = 2
So 14511-59-2 is a valid CAS Registry Number.
InChI:InChI=1/C19H21ClN2O6S/c1-3-28-19(24)22-29(25,26)15-7-4-13(5-8-15)10-11-21-18(23)16-12-14(20)6-9-17(16)27-2/h4-9,12H,3,10-11H2,1-2H3,(H,21,23)(H,22,24)
14511-59-2Relevant academic research and scientific papers
Synthesis technology of glibenclamide
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Paragraph 0043; 0045, (2017/08/25)
The invention provides a novel synthesis technology of a glibenclamide bulk pharmaceuticals. The glibenclamide product is finally prepared by taking sulfamide as a starting raw material through the four steps of a secondary condensation reaction, a compounding reaction, a dealcoholization reaction and refining. The technology has the advantages of being high in yield, low in purity, easy and convenient to operate, suitable for industrialized production and the like.
Hydroxyl-Substituted sulfonylureas as potent inhibitors of specific [3H]Glyburide binding to rat brain synaptosomes
Hill, Ronald A.,Rudra, Sonali,Peng, Bo,Roane, David S.,Bounds, Jeffrey K.,Zhang, Yang,Adloo, Ahmad,Lu, Tiansheng
, p. 2099 - 2113 (2007/10/03)
We are seeking to discover potent CNS-active sulfonylureas with structural features that allow for the formation of several types of prodrugs. We report herein the syntheses of compounds comprising an initial series of hydroxyl-substituted analogues of the potent ATP-sensitive potassium channel blockers glyburide (glibenclamide) and gliquidone. Somewhat unexpectedly, several of the compounds were found to be comparably potent to glyburide as inhibitors of specific [3H]glyburide binding in rat brain preparations.
