23088-23-5

Basic information

• Product Name: METHYL 6-QUINOXALINECARBOXYLATE
• Synonyms: QUINOXALINE-6-CARBOXYLIC ACID METHYL ESTER;RARECHEM AM LA 0028;METHYL 6-QUINOXALINECARBOXYLATE;METHYL QUINOXALINE-6-CARBOXYLATE;6-Quinoxalinecarboxylic acid methyl ester;Methyl 6-quinoxalinecarboxylate 97%
• CAS NO: 23088-23-5
• Molecular Formula: C10H8N2O2
• Molecular Weight: 188.18
• Mol File: 23088-23-5.mol
• Article Data: 3

Chemical Properties

• Melting Point: 99 °C
• Boiling Point: 318.2 °C at 760 mmHg
• Flash Point: 146.3 °C
• Appearance: /
• Density: 1.272 g/cm³
• Vapor Pressure: 0.000366mmHg at 25°C
• Refractive Index: 1.621
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -0.31±0.30(Predicted)
• CAS DataBase Reference: METHYL 6-QUINOXALINECARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 6-QUINOXALINECARBOXYLATE(23088-23-5)
• EPA Substance Registry System: METHYL 6-QUINOXALINECARBOXYLATE(23088-23-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-36/37
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 23088-23-5(Hazardous Substances Data)

Usage

General Description

Methyl 6-quinoxalinecarboxylate is a chemical compound with the molecular formula C??H?N?O?. It is a quinoxaline derivative which is commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is a colorless to pale yellow liquid with a strong, sweet odor, and is insoluble in water but soluble in organic solvents. Methyl 6-quinoxalinecarboxylate is known for its versatile reactivity, making it a valuable chemical in organic synthesis and medicinal chemistry. It is also known for its potential biological activities, including antimicrobial, antiparasitic, and anticancer properties, which makes it an area of interest for pharmaceutical research and development.

InChI:InChI=1/C10H8N2O2/c1-14-10(13)7-2-3-8-9(6-7)12-5-4-11-8/h2-6H,1H3

Upstream product

• 131543-46-9 Glyoxal 
• 36692-49-6 Methyl 3,4-diaminobenzoate 
• 619-05-6 3,4-diaminobenzoic acid 
• 4845-50-5 2,3-dihydroxy-1,4-dioxane 

Downstream Products

• 6925-00-4 quinoxaline-6-carboxylic acid 
• 258503-93-4 quinoxaline-6-carbonyl chloride 
• 90918-37-9 1,2,3,4-tetrahydroquinoxaline-6-carboxylic acid methyl ester 
• 1246383-16-3 2-(2-chloro-4-methoxy-phenyl)-1-quinoxalin-6-yl-ethanone 

Relevant articles and documents

Meta C-H Arylation of Electron-Rich Arenes: Reversing the Conventional Site Selectivity

Controlling site selectivity of C-H activation without using a directing group remains a significant challenge. While Pd(II) catalysts modulated by a mutually repulsive pyridine-type ligand have been shown to favor the relatively electron-rich carbon centers of arenes, reversing the selectivity to favor palladation at the relatively electron-deficient positions has not been possible. Herein we report the first catalytic system that effectively performs meta C-H arylation of a variety of alkoxy aromatics including 2,3-dihydrobenzofuran and chromane with exclusive meta site selectivity, thus reversing the conventional site selectivity governed by native electronic effects. The identification of an effective ligand and modified norbornene (NBE-CO2Me), as well as taking advantage of the statistics, are essential for achieving the exclusive meta selectivity.

INHIBITORS OF HISTONE DEACETYLASE

The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.