23095-03-6

Basic information

• Product Name: Benzenesulfonamide, 3-bromo-4-methoxy-
• CAS NO: 23095-03-6
• Molecular Formula: C7H8BrNO3S
• Molecular Weight: 266.115
• Mol File: 23095-03-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Benzenesulfonamide, 3-bromo-4-methoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonamide, 3-bromo-4-methoxy-(23095-03-6)
• EPA Substance Registry System: Benzenesulfonamide, 3-bromo-4-methoxy-(23095-03-6)

Safety Data

• Hazardous Substances Data: 23095-03-6(Hazardous Substances Data)

Upstream product

• 578-57-4 2-bromoanisole 
• 1129-26-6 4-methoxybenzene sulfonamide 
• 23094-96-4 3-bromo-4-methoxybenzenesulfonyl chloride 

Downstream Products

• 188582-83-4 4-Methoxy-3-(1H-pyrrol-2-yl)-benzenesulfonamide 
• 22117-84-6 3-cyano-4-methoxybenzenesulfonamide 
• 28011-67-8 N-(3-bromo-4-methoxybenzenesulfonyl)acetamide 
• 215187-39-6 2-(2-Methoxy-5-sulfamoyl-phenyl)-pyrrole-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

THERAPEUTIC AGENT FOR INFLAMMATORY DISEASES, AUTOIMMUNE DISEASES, FIBROTIC DISEASES, AND CANCER DISEASES

A therapeutic agent for treating at least one disease selected from the group consisting of inflammatory diseases, autoimmune diseases, fibrotic diseases, and cancer diseases, comprising: at least one selected from the group consisting of a compound represented by the following general formula (1) and pharmacologically acceptable salts thereof as an active ingredient. [In the formula (1), R1 and R2 may be the same or different and each represents a hydrogen atom, a halogen atom, a hydroxyl group, a carboxy group, a cyano group, an optionally substituted C1-6 alkyl group et al.; R3 represents a hydrogen atom; R4 represents an optionally substituted 4- to 10-membered monocyclic heterocyclic group containing 1 to 4 heteroatoms selected from an oxygen atom, a nitrogen atom, and a sulfur atom; X represents a group represented by the following formula: -CH2-, - CH2-CH2-, -CH2-CH2-CH2-, or -CH2-O-CH2-; and Z represents a hydrogen atom or a hydroxyl group.]

Preparation method of 2-methoxy-5-sulfamoylbenzoic acid

The invention provides a preparation method of 2-methoxy-5-sulfamoylbenzoic acid, comprising the following steps: carrying out bromination reaction on 4-methoxybenzenesulfonamide and bromine under theaction of a reducing agent to obtain 3-bromo-4-methoxybenzenesulfonamide; carrying out substitution reaction on 3-bromo-4-methoxybenzenesulfonamide and cuprous cyanide under the action of a catalystto generate 3-cyano-4-methoxybenzenesulfonamide; carrying out alcoholysis on the 3-cyano-4-methoxybenzenesulfonamide and methanol under the catalysis of an acid to obtain 2-methoxy-5-sulfonamide methyl benzoate; hydrolyzing 2-methoxy-5-sulfonamide methyl benzoate under an alkaline condition, and then acidifying to obtain the 2-methoxy-5-sulfamoylbenzoic acid. The preparation method of the 2-methoxy-5-sulfamoylbenzoic acid is mild in reaction condition, simple in process and equipment, convenient to operate and environmentally friendly.

2-'5-(5-CARBAMIMIDOYL-1H-HETEROARYL)-6-HYDROXYBIPHENYL-3-YL!- CARBOXYLIC ACID DERIVATIVES AS FACTOR VIIA INHIBITORS

The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders. Processes for preparing these inhibitors are also disclosed.