23095-14-9

Usage

Uses

Used in Organic Synthesis:
4-BROMO-2-(AMINOSULPHONYL)ANISOLE is used as a key intermediate in organic synthesis for the creation of a variety of chemical compounds. Its unique structure allows for multiple points of reactivity, making it a valuable component in the formation of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-BROMO-2-(AMINOSULPHONYL)ANISOLE is used as a building block for the production of pharmaceuticals. Its incorporation into the molecular structures of drugs aids in the development of new medications with specific therapeutic properties.
Used as a Precursor for Active Pharmaceutical Ingredients:
4-BROMO-2-(AMINOSULPHONYL)ANISOLE is utilized as a precursor in the synthesis of active pharmaceutical ingredients. Its presence in the molecular framework of these ingredients contributes to the overall efficacy and pharmacological profile of the final drug products.
Used in the Development of New Materials:
Beyond its applications in synthesis and the pharmaceutical industry, 4-BROMO-2-(AMINOSULPHONYL)ANISOLE has also been studied for its potential use in the development of new materials. Its unique chemical properties may contribute to the creation of innovative materials with specialized applications.
Used in Chemical Process Development:
4-BROMO-2-(AMINOSULPHONYL)ANISOLE is employed in the research and development of new chemical processes. Its reactivity and structural features make it a candidate for optimizing existing processes or creating new ones that can enhance the efficiency and effectiveness of chemical production.

InChI:InChI=1/C7H8BrNO3S/c1-12-6-3-2-5(8)4-7(6)13(9,10)11/h2-4H,1H3,(H2,9,10,11)

Upstream product

• 104-92-7 1-bromo-4-methoxy-benzene 
• 23095-05-8 5-bromo-2-methoxybenzenesulfonyl chloride 
• 778592-06-6 5-bromo-N-isopropyl-2-methoxy-benzenesulfonamide 
• 1336-21-6 ammonium hydroxide 

Downstream Products

• 446308-82-3 N-benzyl-5-bromo-2-methoxybenzenesulfonamide 
• 52960-57-3 2-methoxyphenylsulfonamide 

Relevant academic research and scientific papers

Design of Benzoxathiazin-3-one 1,1-Dioxides as a New Class of Irreversible Serine Hydrolase Inhibitors: Discovery of a Uniquely Selective PNPLA4 Inhibitor

The design and examination of 4,1,2-benzoxathiazin-3-one 1,1-dioxides as candidate serine hydrolase inhibitors are disclosed, and represent the synthesis and study of a previously unexplored heterocycle. This new class of activated cyclic carbamates provi

Novel N-benzoyl-2-hydroxybenzamide disrupts unique parasite secretory pathway

Toxoplasma gondii is a protozoan parasite that can damage the human brain and eyes. There are no curative medicines. Herein, we describe our discovery of N-benzoyl-2-hydroxybenzamides as a class of compounds effective in the low nanomolar range against T. gondii in vitro and in vivo. Our lead compound, QQ-437, displays robust activity against the parasite and could be useful as a new scaffold for development of novel and improved inhibitors of T. gondii. Our genome-wide investigations reveal a specific mechanism of resistance to N-benzoyl-2-hydroxybenzamides mediated by adaptin-3β, a large protein from the secretory protein complex. N-Benzoyl-2-hydroxybenzamide-resistant clones have alterations of their secretory pathway, which traffics proteins to micronemes, rhoptries, dense granules, and acidocalcisomes/plant-like vacuole (PLVs). N-Benzoyl-2-hydroxybenzamide treatment also alters micronemes, rhoptries, the contents of dense granules, and, most markedly, acidocalcisomes/PLVs. Furthermore, QQ-437 is active against chloroquine- resistant Plasmodium falciparum. Our studies reveal a novel class of compounds that disrupts a unique secretory pathway of T. gondii, with the potential to be used as scaffolds in the search for improved compounds to treat the devastating diseases caused by apicomplexan parasites. Copyright

Novel N-dealkylation of N-alkyl sulfonamides and N,N-dialkyl sulfonamides with periodic acid catalyzed by chromium(III) acetate hydroxide

Chromium(III) acetate hydroxide has been found to be an efficient catalyst for N-dealkylation of N-alkyl sulfonamides and N,N-dialkyl sulfonamides to furnish sulfonamides in good to excellent yields with periodic acid in acetonitrile at room temperature.

Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment

Compounds of formula I: as well as pharmaceutically acceptable salts, hydrates and esters thereof, are disclosed. The compounds are useful for treating or preventing prostaglandin mediated diseases. Pharmaceutical compositions containing such compounds and methods of treatment are also included.