23095-76-3Relevant articles and documents
Preparation of a β-cyclodextrin-based open-tubular capillary electrochromatography column and application for enantioseparations of ten basic drugs
Fang, Linlin,Yu, Jia,Jiang, Zhen,Guo, Xingjie
, (2016/01/29)
An open-tubular capillary electrochromatography column was prepared by chemically immobilized β-cyclodextrin modified gold nanoparticles onto new surface with the pre-derivatization of (3-mercaptopropyl)-trimethoxysilane. The synthesized nanoparticles and the prepared column were characterized by transmission electron microscopy, scanning electron microscopy, infrared spectroscopy and ultraviolet visible spectroscopy. When the column was employed as the chiral stationary phase, no enantioselectivity was observed for ten model basic drugs. So β-cyclodextrin was added to the background electrolyte as chiral additive to expect a possible synergistic effect occurring and resulting in a better separation. Fortunately, significant improvement in enantioselectivity was obtained for ten pairs of drug enantiomers. Then, the effects of β-cyclodextrin concentration and background electrolyte pH on the chiral separation were investigated. With the developed separation mode, all the enantiomers (except for venlafaxine) were baseline separated in resolutions of 4.49, 1.68, 1.88, 1.57, 2.52, 2.33, 3.24, 1.63 and 3.90 for zopiclone, chlorphenamine maleate, brompheniramine maleate, dioxopromethazine hydrochloride, carvedilol, homatropine hydrobromide, homatropine methylbromide, venlafaxine, sibutramine hydrochloride and terbutaline sulfate, respectively. Further, the possible separation mechanism involved was discussed.
Enantioselective absorption of enantiomers with maleic anhydride-β-cyclodextrin modified magnetic microspheres
Huang, Jun,Su, Ping,Wu, Jingwei,Yang, Yi
, p. 58514 - 58521 (2015/02/19)
Multifunctional magnetic microspheres have enormous potential in diverse fields. In this work, surface chiral-modified magnetic microspheres as chiral selectors, are prepared by polymerizing maleic anhydride-β-cyclodextrin (MAH-β-CD) for the enantioselective absorption of four enantiomers. The successful grafting of MAH-β-CD onto the surface of magnetic microspheres is confirmed by transmission electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy and thermogravimetric analysis. The prepared functional microspheres have a three-ply structure with an average particle size of 550 nm and a high saturation magnetization of 60 emu g-1. The amount of MAH-β-CD modified on the P(MBAAm)@Fe3O4 was about 149.1 mg g-1. The analysis results of specific rotation and capillary electrophoresis reveal that the MAH-β-CD-modified Fe3O4 microspheres show stronger complexation of (-)-enantiomers than (+)-enantiomers. In addition, the MAH-β-CD-modified Fe3O4 microspheres have stronger enantioselective absorption for double-ring chiral compounds. These chiral-functionalized magnetic microspheres are therefore expected to be an efficient and economical chiral separation method for use in further research.