230975-30-1

Basic information

• Product Name: 1,3-Bis[4-(2-methoxyethyl)phenoxy]-
• Synonyms: 1,3-Bis[4-(2-methoxyethyl)phenoxy]-;1,3-Bis[4-(2-Methoxyethyl)phenoxy]-2-propanol;Metoprolol Bis Propanol IMpurity;Metoprolol Impurity P
• CAS NO: 230975-30-1
• Molecular Formula: C21H28O5
• Molecular Weight: 360.44402
• Product Categories: Aromatics;Impurities;Aromatics, Impurities
• Mol File: 230975-30-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 491.1±40.0 °C(Predicted)
• Appearance: /
• Density: 1.112±0.06 g/cm3(Predicted)
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 13.37±0.20(Predicted)
• CAS DataBase Reference: 1,3-Bis[4-(2-methoxyethyl)phenoxy]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Bis[4-(2-methoxyethyl)phenoxy]-(230975-30-1)
• EPA Substance Registry System: 1,3-Bis[4-(2-methoxyethyl)phenoxy]-(230975-30-1)

Safety Data

• Hazardous Substances Data: 230975-30-1(Hazardous Substances Data)

Usage

Uses

Metoprolol (M338790)

Upstream product

• 56718-71-9 4-(2-methoxyethyl)phenol 
• 106-89-8 epichlorohydrin 

Relevant articles and documents

Continuous and convergent access to vicinyl amino alcohols

Five active pharmaceutical ingredients (APIs) containing the vicinyl amino alcohol moiety were synthesized using a convergent chemical assembly system. The continuous system is composed of four flow reaction modules: biphasic oxidation, Corey-Chaykovsky epoxidation, phenol alkylation, and epoxide aminolysis. Judicious choice of reagents and module order allowed for two classes of β-amino alcohols, aryl and aryloxy, to be synthesized in good (27-69%) overall yields.