23110-99-8Relevant articles and documents
Selective inhibition of Trypanosoma cruzi GAPDH by "bi-substrate" analogues
Ladame, Sylvain,Faure, Regis,Denier, Colette,Lakhdar-Ghazal, Faouzi,Willson, Michele
, p. 2070 - 2072 (2007/10/03)
A new series of "bi-substrate" analogues have been synthesized as potential inhibitors of the glyceraldehyde-3-phosphate dehydrogenase and one lead compound has been identified that inhibits the enzyme from Trypanosoma cruzi with good affinity and very high (50-fold) specificity. The Royal Society of Chemistry 2005.