23112-88-1Relevant articles and documents
Azepine- or Azocine-Embedded Hexabenzocoronene Derivatives as Nitrogen-Doped Saddle or Saddle-Helix Nanographenes
An, Peng,He, Run-Ying,Li, Ranran,Ma, Bin,Xiao, Ming-Jun,Zhang, Bin,Zhang, Yi-Kang
supporting information, p. 24478 - 24483 (2021/10/19)
Two novel nitrogen-doped, hexa-peri-hexabenzocoronene (HBC)-based nanographenes (NGs) 1 and 2 bearing an azepine and an azocine at the fjord region, respectively, were synthesized and characterized. Notably, structure 1 was synthesized by Diels–Alder reac
A Compact and Synthetically Accessible Fluorine-18 Labelled Cyclooctyne Prosthetic Group for Labelling of Biomolecules by Copper-Free Click Chemistry
Murrell, Emily,Kovacs, Michael S.,Luyt, Leonard G.
, p. 1625 - 1628 (2018/07/31)
A new fluorine-containing azadibenzocyclooctyne (ADIBO-F) was designed using a synthetically accessible pathway. The fluorine-18 prosthetic group was prepared from its toluenesulfonate precursor and isolated in 21–35 % radiochemical yield in 30 minutes of synthetic time. ADIBO-F has been incorporated into azide-functionalized, cancer-targeting peptides through a strain-promoted alkyne–azide cycloaddition with high radiochemical yields and purities. The final products are novel peptide-based positron emission tomography (PET) imaging agents that possess high affinities for their targets, growth hormone secretagogue receptor 1a (GHSR-1a) and gastrin-releasing peptide receptor (GRPR), with IC50 values of 9.7 and 0.50 nm, respectively. This is a new and rapid labelling option for the incorporation of fluorine-18 into biomolecules for PET imaging.
Aza dibenzo link octyne compound and method for preparing the same
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, (2017/02/02)
The invention discloses a heterocyclic nitrogen-dibenz-cyclooctyne class compound and a preparation method of the heterocyclic nitrogen-dibenz-cyclooctyne class compound, and belongs to the field of organic chemical synthesis. The structural general formula of the compound is shown in the formula I. 5-dibenz cycloheptene ketene serves as a starting material, final end product heterocyclic nitrogen-dibenz-cyclooctyne hydrochloride is obtained through the reactions of oximation, Beckmann rearrangement, amid reduction, protection, addition, debromination, deprotection and the like, and the total yield is higher than 73.6%. The raw material is easy to obtain, after-treatment is convenient and easy to operate, and the total yield is high. The heterocyclic nitrogen-dibenz-cyclooctyne class compound without a substituent on nitrogen atoms is synthezied for the first time, a novel method can be provided for synthesizing a heterocyclic nitrogen-dibenz-cyclooctyne class compound with different substituents on the nitrogen atoms, especially for synthesizing multiple heterocyclic nitrogen-dibenz-cyclooctyne class compounds with the different substituents on the nitrogen atoms, wherein the heterocyclic nitrogen-dibenz-cyclooctyne class compounds are not easy to prepare through other methods, a product of the heterocyclic nitrogen-dibenz-cyclooctyne class compound can serve as the raw material, and H on nitrogen is replaced by the needed R base.
