1255942-08-5 Usage
Uses
Used in Bioconjugation:
DBCO-PEG4-amine is used as a bioconjugation agent for the formation of stable amide bonds with carboxyl groups or activated esters. Its extended PEG spacer arm improves the water solubility of the resulting conjugates, which is crucial for applications in aqueous environments.
Used in Drug Delivery Systems:
In the pharmaceutical industry, DBCO-PEG4-amine is used as a component in the development of drug delivery systems. The hydrophilic PEG spacer arm can help improve the solubility and bioavailability of drugs, potentially enhancing their therapeutic efficacy.
Used in Diagnostics:
DBCO-PEG4-amine can be employed in the creation of diagnostic tools, where its ability to form stable amide bonds with target molecules can be leveraged for the detection and analysis of various biomarkers.
Used in Materials Science:
In the field of materials science, DBCO-PEG4-amine can be utilized for the synthesis of functional materials with tailored properties. The PEG spacer arm can contribute to improved hydrophilicity, while the DBCO group enables efficient and selective Click Chemistry reactions for the assembly of complex structures.
Used in Research and Development:
DBCO-PEG4-amine is also valuable in research and development settings, where its reactivity and PEGylation capabilities can be harnessed for the creation of novel bioconjugates and the study of their properties and interactions with biological systems.
Check Digit Verification of cas no
The CAS Registry Mumber 1255942-08-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,5,5,9,4 and 2 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1255942-08:
(9*1)+(8*2)+(7*5)+(6*5)+(5*9)+(4*4)+(3*2)+(2*0)+(1*8)=165
165 % 10 = 5
So 1255942-08-5 is a valid CAS Registry Number.
1255942-08-5Relevant articles and documents
AZA-DIBENZOCYCLOOCTYNES AND METHODS OF MAKING AND USING SAME
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Page/Page column 7-8, (2012/02/06)
Convenient methods of preparing aza-dibenzocyclooctynes are disclosed herein. Aza-dibenzocyclooctynes attached to a surface are also disclosed herein. Aza-dibenzocyclooctynes can be reacted with azides to form heterocyclic compounds. Such reactions can be useful in a wide variety of applications including, for example, labeling surfaces.
Surface functionalization using catalyst-free azide-alkyne cycloaddition
Kuzmin, Alexander,Poloukhtine, Andrei,Wolfert, Margreet A.,Popik, Vladimir V.
, p. 2076 - 2085 (2011/07/09)
The utility of catalyst-free azide-alkyne [3 + 2] cycloaddition for the immobilization of a variety of molecules onto a solid surface and microbeads was demonstrated. In this process, the surfaces are derivatized with aza-dibenzocyclooctyne (ADIBO) for the immobilization of azide-tagged substrates via a copper-free click reaction. Alternatively, ADIBO-conjugated molecules are anchored to the azide-derivatized surface. Both immobilization techniques work well in aqueous solutions and show excellent kinetics under ambient conditions. We report an efficient synthesis of aza-dibenzocyclooctyne (ADIBO), thus far the most reactive cyclooctyne in cycloaddition to azides. We also describe convenient methods for the conjugation of ADIBO with a variety of molecules directly or via a PEG linker.
