231278-08-3Relevant articles and documents
QUINAZOLINE DERIVATIVES USEFUL AS SELECTIVE HDAC6 INHIBITORS
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Paragraph 000185, (2021/12/31)
Provided herein is a compound of Formula (I): or a pharmaceutically acceptable salt thereof, wherein the variables are defined herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I) and methods of using the compo
An alternative synthesis of the non-small cell lung carcinoma drug afatinib
Kovacevic, Tatjana,Mesic, Milan,Avdagic, Amir,Zegarac, Miroslav
supporting information, p. 4180 - 4182 (2018/10/24)
Afatinib (BIBW2992) is the anticancer drug developed by Boehringer Ingelheim. This work is reporting the synthesis of the afatinib using a new route by Ullmann-Goldberg reaction from corresponding 4-anilinoquinazoline iodide as the last step in the synthesis. This route was not described previously and it could be used for synthesis of afatinib analogues.
Bicyclic heteroaromatic compounds as protein tyrosine kinase inhibitors
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Page/Page column 37; 38, (2015/12/18)
A pharmaceutical formulation comprising the compound of formula