231278-22-1

Basic information

• Product Name: 6-iodo-(4-(3-fluorobenzyloxy)-3-methoxyphenyl-quinazolin-4-yl)amine
• Synonyms: 6-iodo-(4-(3-fluorobenzyloxy)-3-methoxyphenyl-quinazolin-4-yl)amine
• CAS NO: 231278-22-1
• Molecular Weight: 501.299
• Mol File: 231278-22-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 6-iodo-(4-(3-fluorobenzyloxy)-3-methoxyphenyl-quinazolin-4-yl)amine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-iodo-(4-(3-fluorobenzyloxy)-3-methoxyphenyl-quinazolin-4-yl)amine(231278-22-1)
• EPA Substance Registry System: 6-iodo-(4-(3-fluorobenzyloxy)-3-methoxyphenyl-quinazolin-4-yl)amine(231278-22-1)

Safety Data

• Hazardous Substances Data: 231278-22-1(Hazardous Substances Data)

Upstream product

• 231278-66-3 4-((3-fluorobenzyl)oxy)-3-methoxyaniline 
• 98556-31-1 4-chloro-6-iodoquinazoline 
• 630413-35-3 1-[(3-fluorobenzyl)oxy]-2-methoxy-4-nitrobenzene 
• 456-41-7 1-(Bromomethyl)-3-fluorobenzene 
• 3251-56-7 2-methoxy-4-nitrophenol 

Downstream Products

• 231278-72-1 5-{4-[4-(3-fluoro-benzyloxy)-3-methoxy-phenylamino]-quinazolin-6-yl}-furan-2-carbaldehyde 

Relevant articles and documents

Bicyclic heteroaromatic compounds as protein tyrosine kinase inhibitors

A pharmaceutical formulation comprising the compound of formula

Optimization and SAR for dual ErbB-1/ErbB-2 tyrosine kinase inhibition in the 6-furanylquinazoline series

Synthetic modifications on a 6-furanylquinazoline scaffold to optimize the dual ErbB-1/ErbB-2 tyrosine kinase inhibition afforded consistent SAR whereby a 4-(3-fluorobenzyloxy)-3-haloanilino provided the best enzyme potency and cellular selectivity. Changes made to the 6-furanyl group had little impact on the enzyme activity, but appeared to dramatically affect the cellular efficacy. The discovery of lapatinib emerged from this work.