231278-79-8

Basic information

• Product Name: N-(1-(3-fluorobenzyl)-1H-indazol-5-yl)-6-iodoquinazolin-4-amine
• Synonyms: N-(1-(3-fluorobenzyl)-1H-indazol-5-yl)-6-iodoquinazolin-4-amine
• CAS NO: 231278-79-8
• Molecular Weight: 495.298
• Mol File: 231278-79-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: N-(1-(3-fluorobenzyl)-1H-indazol-5-yl)-6-iodoquinazolin-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(1-(3-fluorobenzyl)-1H-indazol-5-yl)-6-iodoquinazolin-4-amine(231278-79-8)
• EPA Substance Registry System: N-(1-(3-fluorobenzyl)-1H-indazol-5-yl)-6-iodoquinazolin-4-amine(231278-79-8)

Safety Data

• Hazardous Substances Data: 231278-79-8(Hazardous Substances Data)

Upstream product

• 529508-58-5 1-(3-fluorobenzyl)-5-nitro-1H-carbazole 
• 16064-08-7 6-iodo-4-hydroxyquinazoline 
• 98556-31-1 4-chloro-6-iodoquinazoline 
• 202197-31-7 1-(3-fluorobenzyl)-1H-indazol-5-ylamine 
• 456-41-7 1-(Bromomethyl)-3-fluorobenzene 
• 5401-94-5 5-nitroindazole 
• 132131-24-9 5-iodoanthranilonitrile 

Relevant articles and documents

Hetero-aromatic compound and its use in medicine

The invention provides a hetero-aromatic compound or a stereisomer, geometric isomer, tautomer, despinner, nitrogen oxide, hydrate, solvate, metabolite, metabolism precursor and pharmaceutically acceptable salt or prodrug thereof, which is used for treating proliferative diseases. The invention also discloses a pharmaceutical composition containing the compound and an application of the compound or pharmaceutical composition thereof in preparation of a medicine for treating proliferative diseases.

PHOSPHORUS CONTAINING QUINAZOLINE COMPOUNDS AND METHODS OF USE

Disclosed are novel quinazoline derivatives containing phosphorus substitutions and methods for the treatment of hyperproliferative diseases (e.g. cancer) using the compounds. These compounds are type I receptor protein kinase inhibitors useful in treating disorders related to abnormal protein kinase activities such as cancer and inflammation in mammals. Also disclosed are pharmaceutical compositions containing the compounds, methods for the preparation of the compounds and their pharmaceutically acceptable salts.