231296-03-0Relevant articles and documents
Synthesis of 5-Amino-2,5-dihydro-1H-benzo[b]azepines Using a One-Pot Multibond Forming Process
Sharif, Salaheddin A. I.,Calder, Ewen D. D.,Delolo, Fábio G.,Sutherland, Andrew
, p. 6697 - 6706 (2016/08/16)
Rapid access to allylic trichloroacetimidates bearing a 2-allylaminoaryl group from readily available 2-iodoanilines combined with a one-pot multibond forming process has allowed the efficient synthesis of a series of 5-amino-2,5-dihydro-1H-benzo[b]azepin
On water: Catalyst-free chemoselective synthesis of highly functionalized tetrahydroquinazolines from 2-aminophenylacrylate
Saunthwal, Rakesh K.,Patel, Monika,Tiwari, Rakesh K.,Parang, Keykavous,Verma, Akhilesh K.
supporting information, p. 1434 - 1441 (2015/03/18)
A green and catalyst-free atom-ecomonic straightforward tandem approach for the synthesis of highly functionalized tetrahydroquinazolines by the reaction of 2-aminophenylacrylates with isothiocyanates using water as an environmentally friendly solvent via amidation and concomitant chemoselective Michael-addition is described. This journal is
Cu(II)-catalyzed tandem synthesis of 2-imino[1,3]benzothiazines from 2-aminoaryl acrylates via thioamidation and concomitant chemoselective thia-Michael addition
Saunthwal, Rakesh K.,Patel, Monika,Kumar, Sushil,Verma, Akhilesh K.
supporting information, p. 677 - 681 (2015/01/30)
An efficient copper-catalyzed tandem approach for the synthesis of 2-imino[1,3]benzothiazines by the reaction of easily accessible 2-aminoaryl acrylates with isothiocyanates via in situ thioamidation and concomitant chemoselective intramolecular thia-Mich
A direct access to bioactive fused N-heterocyclic acetic acid derivatives
Adepu, Raju,Rajitha,Ahuja, Dipali,Sharma, Atul Kumar,Ramudu,Kapavarapu, Ravikumar,Parsa, Kishore V. L.,Pal, Manojit
, p. 2514 - 2518 (2014/04/17)
A Cu-catalyzed new sequence involving the Ullmann type intermolecular C-C followed by an intramolecular C-N coupling and then intramolecular aza-Michael type addition (and oxidation) in a single pot afforded various fused N-heterocyclic acetic acid derivatives as inhibitors of PDE4. This journal is the Partner Organisations 2014.
One pot synthesis of pyrrolo[3,4-c]quinolinone/pyrrolo[3,4-c]quinoline derivatives from 2-aminoarylacrylates/2-aminochalcones and tosylmethyl isocyanide (TosMIC)
Lu, Xin-Mou,Li, Jian,Cai, Zhong-Jian,Wang, Rong,Wang, Shun-Yi,Ji, Shun-Jun
supporting information, p. 9471 - 9477 (2015/02/19)
An efficient and practical synthetic approach to access to 2H-pyrrolo[3,4-c]quinolin-4(5H)-one/2H-pyrrolo[3,4-c]quinoline derivatives by the reaction of 2-aminoarylacrylates/2-aminochalcones and tosylmethyl isocyanide (TosMIC) via a one pot van Leusen rea
Synthesis of 2-acylindole-3-acetic acids: A novel base-mediated indole synthesis
Nakao, Kazunari,Murata, Yoshinori,Koike, Hiroki,Uchida, Chikara,Kawamura, Kiyoshi,Mihara, Sachiko,Hayashi, Shigeo,Stevens, Rodney W.
, p. 7269 - 7271 (2007/10/03)
An efficient and expedient synthetic route to 2-acylindole-3-acetic acids is described. This work first demonstrates a one-pot room-temperature indole ring construction via the in situ generation of indoline intermediate.
2,3-substituted indole compounds as anti-inflammatory and analgesic agents
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, (2008/06/13)
This invention provides a compound of the following formula: or the pharmaceutically acceptable salts thereof wherein Z is OH, C1-6 alkoxy, —NR2R3 or heterocycle; Q is selected from the following: (a) an optionally substituted phenyl, (b) an optionally substituted 6-membered monocyclic aromatic group containing one, two, three or four nitrogen atom(s), (c) an optionally substituted 5-membered monocyclic aromatic group containing one heteroatom selected from O, S and N and optionally containing one, two or three nitrogen atom(s) in addition to said heteroatom, (d) an optionally substituted C3-7 cycloalkyl and (e) an optionally substituted benzo-fuzed heterocycle; R1 is hydrogen, C1-4 alkyl or halo; R2 and R3 are independently hydrogen, OH, C1-4 alkoxy, C1-4 alkyl or C1-4 alkyl substituted with halo, OH, C1-4 alkoxy or CN; X is independently selected from H, halo, C1-4 alkyl, halo-substituted C1-4 alkyl, OH, C1-4 alkoxy, halo-substituted C1-4 alkoxy, C1-4 alkylthio, NO2, NH2, di-(C1-4 alkyl)amino and CN; and n is 0, 1, 2, 3 and 4.This invention also provides a pharmaceutical composition useful for the treatment of a medical condition in which prostaglandins are implicated as pathogens.
Tetrazolylalkyl indole compounds as anti-inflammatory and analgesic agents
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, (2008/06/13)
This invention provides a compound of the following formula: or the pharmaceutically acceptable salts thereof wherein Z is tetrazolyl optionally substituted with a substituent selected from C1-4 alkyl and halosubstituted C1-4 alkyl;A is C1-6 alkylene; Q is selected from the following groups: (a) optionally substituted phenyl; (b) an optionally substituted, partially saturated, fully saturated or fully unsaturated five to six membered monocyclic group having one to three heteroatoms; and (c) an optionally substituted, bicyclic group consisting of two fused partially saturated, fully saturated or fully unsaturated five or six membered rings independently and optionally having one to four heteroatoms; X is halogen, C1-4 alkyl, halosubstituted C1-4 alkyl, OH, C1-4 alkoxy or the like; and n is 0, 1, 2, 3 or 4. This invention also provides a pharmaceutical composition useful for the treatment of a medical condition in which prostaglandins are implicated as pathogens.
