23133-72-4

Upstream product

• 527-61-7 2,6-dimethyl-1,4-benzoquinone 
• 2431-91-6 4-methoxy-2,6-dimethylphenol 
• 75-36-5 acetyl chloride 

Downstream Products

• 496035-34-8 4-methoxy-2,6-dimethylphenyl (4Z,6S,7R,8S)-7-(t-butyldimethylsilyloxy)-9-(p-methoxybenzyloxy)-4,6,8-trimethylnon-4-enoate 
• 827603-09-8 (4-methoxy-2,6-dimethylphenyl) (2S,3S,4S,5S,6S,7Z)-2-[(2Z,4S,5R,6S)-5-(t-butyldimethylsilyloxy)-7-(p-methoxybenzyloxy)-2,4,6-trimethylhept-2-enyl]-3-hydroxy-5-(p-methoxybenzyloxy)-4,6-dimethyldeca-7,9-dienoate 

Relevant academic research and scientific papers

A second-generation total synthesis of (+)-discodermolide: The development of a practical route using solely substrate-based stereocontrol

(Chemical Equation Presented). A novel total synthesis of the complex polyketide (+)-discodermolide, a promising anticancer agent of sponge origin, has been completed in 7.8% overall yield over 24 linear steps, with 35 steps altogether. This second-genera

SYNTHESIS OF DISCODERMOLIDE

The invention relates to a process for preparing discodermolide, for preparing intermediates for the manufacture of discodermolide and discodermolide analogues and to the intermediates obtained during the process. Wherein the process proceeds via a tetrae