23141-82-4

Basic information

• Product Name: 3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
• Synonyms: 3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
• CAS NO: 23141-82-4
• Molecular Weight: 263.298
• Mol File: 23141-82-4.mol
• Article Data: 1

Chemical Properties

• Melting Point: 208-210 °C
• Boiling Point: 570.2±60.0 °C(Predicted)
• Density: 1.606±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide(23141-82-4)
• EPA Substance Registry System: 3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide(23141-82-4)

Safety Data

• Hazardous Substances Data: 23141-82-4(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 58-93-5 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide 

Relevant articles and documents

Photolytic decomposition of hydrochlorothiazide

Hydrochlorothiazide decomposes upon irradiation with near-UV light (λ > 310 nm) both in methanol and aqueous solutions. In the photolysis the chlorine substituent is removed to be replaced by either -H or -OR from the solvent ROH. Hydrolysis of the thiadiazine ring is superimposed upon the dechlorination. The presence of oxygen inhibits the decomposition. The mechanism of the photolysis is suggested to involve cation radical formation which facilitates the hydrolysis step. 5-Chloro-2,4-disulphonamido-aniline, the normal hydrolysis product from hydrochlorothiazide, is also susceptible to photolytic dechlorination by a similar mechanism.