23145-05-3

Basic information

• Product Name: 5-Chlorobenzofuran
• Synonyms: 5-Chlorobenzofuran;Benzofuran, 5-chloro-;5-Chlorobenzo[b]furan
• CAS NO: 23145-05-3
• Molecular Formula: C₈H₅ClO
• Molecular Weight: 152.58
• Mol File: 23145-05-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 209.5 °C at 760 mmHg
• Flash Point: 80.5 °C
• Appearance: /
• Density: 1.289 g/cm³
• Vapor Pressure: 0.292mmHg at 25°C
• Refractive Index: 1.615
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 5-Chlorobenzofuran(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Chlorobenzofuran(23145-05-3)
• EPA Substance Registry System: 5-Chlorobenzofuran(23145-05-3)

Safety Data

• Hazardous Substances Data: 23145-05-3(Hazardous Substances Data)

Usage

General Description

5-Chlorobenzofuran is an organic compound consisting of a benzene ring fused with a furan ring and a chlorine atom located at the 5-position. It is used as a building block in the synthesis of various pharmaceuticals and agrochemicals. 5-Chlorobenzofuran is a known mutagen and may have harmful effects on aquatic organisms. It is also classified as a potential human carcinogen. The compound is primarily produced by chlorination of benzofuran and is commonly used in chemical research and industrial applications.

InChI:InChI=1/C8H5ClO/c9-7-1-2-8-6(5-7)3-4-10-8/h1-5H

Upstream product

• 3261-05-0 5-chlorobenzofuran-3(2H)-one 

Downstream Products

• 100914-68-9 (5-chloro-1-benzofuran-2-yl)(phenyl)methanone 
• 24472-98-8 5-Chloro-2-(4-methoxy-phenyl)-benzofuran 
• 18761-36-9 5-chloro-2-phenylbenzofuran 

Relevant articles and documents

Total synthesis of the 2-arylbenzo[b]furan-containing natural products from Artocarpus

In this study, 2-arylbenzo[b]furan-containing derivatives moracin C (1) and moracin M (4), the natural products from Artocarpus, have been synthesized in highest overall yield to date (1, 7 steps with an overall yield of 41.9%; 4, 6 steps with an overall yield of 56.3%), and we also report the first total synthesis of artoindonesianin B-1 (2), another member of this family, in the same route (8 steps with an overall yield of 11.3%). This discovery provides a concise route for preparing enough amounts of 1, 2, and 4 as well as 2-arylbenzo[b]furan-containing natural product-like analogs (71-74) to explore the biological potential.