23145-95-1

Usage

Uses

Used in Pharmaceutical Research and Development:
1-(4-Isopropylbenzyl)piperazine is used as a precursor in the synthesis of various pharmacological compounds for the development of new medications. Its unique structure allows for the creation of diverse drug candidates with potential therapeutic applications.
Used in Medical Treatments:
1-(4-Isopropylbenzyl)piperazine is being investigated for its potential use in the treatment of various medical conditions. Its specific role in these treatments is still under research, but its chemical properties make it a promising candidate for further study and development.
Used in Industrial Applications:
Beyond its pharmaceutical uses, 1-(4-Isopropylbenzyl)piperazine may also have applications in other industries. Its versatility and chemical properties could make it suitable for a range of purposes, although specific uses would depend on the industry's requirements and the compound's compatibility with other materials and processes.
Used in Drug Synthesis as an Intermediate:
1-(4-Isopropylbenzyl)piperazine is utilized as an intermediate in the synthesis of pharmaceutical drugs. Its role in this process is crucial, as it contributes to the formation of the final drug product, ensuring the desired therapeutic effects and efficacy.

InChI:InChI=1/C14H22N2/c1-12(2)14-5-3-13(4-6-14)11-16-9-7-15-8-10-16/h3-6,12,15H,7-11H2,1-2H3/p+2

Upstream product

• 110-85-0 piperazine 
• 2051-18-5 4-isopropylbenzyl chloride 
• 84418-44-0 tert-butyl 4-(p-isopropylbenzyl)piperazine-1-carboxylate 

Downstream Products

• 84418-41-7 1-(9-Fluorenylmethyl)-4-(p-isopropylbenzyl)piperazine 
• 1345843-90-4 ethyl 2-(4-(4-isopropylbenzyl)piperazin-1-yl)acetate 
• 1345843-72-2 2-(4-(4-isopropylbenzyl)piperazin-1-yl)acetohydrazide 

Relevant academic research and scientific papers

PROCASPASE-ACTIVATING COMPOUNDS AND COMPOSITIONS

The invention provides compounds and compositions useful for the modulation of certain enzymes. The compounds and compositions can induce of cell death, particularly cancer cell death. The invention also provides methods for the synthesis and use of the compounds and compositions, including the use of compounds and compositions in therapy for the treatment of cancer and selective induction of apoptosis in cells.

Piperazino-Functionalized Silica Gel as a Deblocking-Scavenging Agent for the 9-Fluorenylmethyloxycarbonyl Amino-Protecting Group

Bonding cyclic secondary amino residues to the surface of silica gel has given insoluble reagents capable of deblocking the 9-fluorenylmethyloxycarbonyl amino-protecting group and at the same time scavenging the dibenzofulvene (DBF) liberated in the deblocking process.A piperazino silica reagent 6 bearing approximately 1.1 mequiv of NH/g was easiest to prepare by reaction of trimethoxysilane 5 with chromatographic-grade silica.After use, spent reagent could be regenerated by treatment with excess piperidine.Piperidino silicas 14 and 15 were made similarly.For the amino-functionalized silica reagents and a variety of simple cyclic secondary amines (piperazine, piperidine, etc.) the existence of an equilibrium (eq 3) between DBF (2) and adduct 7 has been established with the position of equilibrium being dependent on the nature of the amine, solvent, etc.Both deblocking and attainment of equilibrium were faster in Me2SO than in chloroform or dichloromethane.With piperazines in Me2SO the equilibrium was shifted toward complete scavenging by precipitation of the adduct from the reaction medium.