23148-51-8

Upstream product

• 99-91-2 para-chloroacetophenone 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 107-91-5 cyanoacetic acid amide 
• 110-89-4 piperidine 
• 109-94-4 formic acid ethyl ester 
• 40160-35-8 Sodium; (Z)-3-(4-chloro-phenyl)-3-oxo-propen-1-olate 

Downstream Products

• 1242622-21-4 O-[6-(4-chlorophenyl)-3-cyanopyrimidin-2-yl] O,O-diisopropyl phosphorothionate 
• 84596-41-8 2-Chloro-6-(4-chlorophenyl)-3-pyridinecarbonitrile 
• 147269-30-5 [1-{[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propylcarbamoyl]-methyl}-6-(4-chloro-phenyl)-2-oxo-1,2-dihydro-pyridin-3-yl]-carbamic acid benzyl ester 
• 147283-30-5 {6-(4-Chloro-phenyl)-2-oxo-1-[(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-methyl]-1,2-dihydro-pyridin-3-yl}-carbamic acid benzyl ester 
• 147283-22-5 [6-(4-Chloro-phenyl)-2-oxo-1,2-dihydro-pyridin-3-yl]-carbamic acid benzyl ester 
• 147269-16-7 6-(4-Chloro-phenyl)-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid 

Relevant academic research and scientific papers

Is the herbicidal activity of 3-cyanopyridin-2-yl phosphates related to phosphatase?

The herbicidal activity of 3-cyanopyridin-2-yl phosphates, which were designed according to the idea of a mechanism-based inactivator, is probably related to a phosphatase. Taylor & Francis Group, LLC.

Synthesis of N-glycosylated pyridines as new antimetabolite agents

Condensation of cyanoacetamide and cyanothioacetamide with the sodium salts of α-(hydroxymethylene)alkanones afforded the pyridine-2(1H)-ones and their corresponding thiones 3. Compounds 3 served as a key intermediates for the synthesis of N-glycosylated pyridines.

Nonpeptidic inhibitors of human leukocyte elastase. 2. Design, synthesis, and in vitro activity of a series of 3-amino-6-arylopyridin-2-one trifluoromethyl ketones

A series of potent nonpeptidic inhibitors of the enzyme human leukocyte elastase (HLE) is reported. These inhibitors contain a 3-amino-2-pyridone ring as a central template in which the pyridone carbonyl and 3-position NH group are thought to form important hydrogen bonding interactions with the Val-216 residue of HLE. Substitution of the 6-position of the pyridone ring by various alkyl and aryl groups was found to afford increases in the in vitro potency of these inhibitors. A 6-position phenyl group, compound 10f, was found to result in a large increase in binding affinity, which was not obtained when the phenyl group was placed in either the 4- or 5-position of the molecule. Compound 10f was found to have good selectivity for HLE over other proteolytic enzymes, with the exception of bovine pancreatic chymotrypsin (BPC). Substitution of the 6-phenyl group in these molecules was found to decrease binding affinity for BPC without adversely affecting affinity for HLE.

1-Benzoyl-3-(arylphyridyl)urea compounds

The present invention is directed to 1-benzoyl-3-(arylpyridyl)urea compounds useful as insecticides.