2315-81-3

Basic information

• Product Name: 3-CHLORO-4-HYDROXYBENZONITRILE
• Synonyms: Benzonitrile, 3-chloro-4-hydroxy-;2-Chloro-4-cyanophenol;4-Cyano-2-chlorophenol;BUTTPARK 43\57-94;3-CHLORO-4-HYDROXYBENZONITRILE
• CAS NO: 2315-81-3
• Molecular Formula: C₇H₄ClNO
• Molecular Weight: 153.57
• Product Categories: Phenols;Phenyls & Phenyl-Het;Aromatic Nitriles;Phenyls & Phenyl-Het;Chlorine Compounds;Nitriles
• Mol File: 2315-81-3.mol
• Article Data: 9

Chemical Properties

• Melting Point: 150 °C
• Boiling Point: 266℃
• Flash Point: 115℃
• Appearance: /
• Density: 1.41
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 6.37±0.18(Predicted)
• CAS DataBase Reference: 3-CHLORO-4-HYDROXYBENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-4-HYDROXYBENZONITRILE(2315-81-3)
• EPA Substance Registry System: 3-CHLORO-4-HYDROXYBENZONITRILE(2315-81-3)

Safety Data

• Hazard Codes: Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39
• RIDADR: 3276
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 2315-81-3(Hazardous Substances Data)

Usage

Chemical Properties

off-white crytalline

InChI:InChI=1/C7H4ClNO/c8-6-3-5(4-9)1-2-7(6)10/h1-3,10H

Upstream product

• 767-00-0 4-cyanophenol 
• 1428636-98-9 C₈H₈ClNO₂ 
• 102151-33-7 3-Chloro-4-methoxybenzonitrile 
• 66422-84-2 4-benzyloxy-3-chlorobenzaldehyde 
• 2420-16-8 4-hydroxy-3-chlorobenzaldehyde 
• 431998-28-6 C₁₄H₁₂NO₂Cl 
• 142247-74-3 4-(benzyloxy)-3-chlorobenzonitrile 
• 3964-56-5 4-bromo-2-chlorophenol 
• 544-92-3 copper(I) cyanide 
• 142247-73-2 4-acetoxy-3-chloro-benzonitrile 

Downstream Products

• 101607-31-2 3,3'-dichloro-4,4'-but-2t-enediyldioxy-di-benzonitrile 
• 101579-31-1 3,3'-dichloro-4,4'-but-2-ynediyldioxy-di-benzonitrile 
• 943141-58-0 3-chloro-4-(trifluoromethanesulfonyloxy)benzonitrile 
• 1079042-84-4 C₁₄H₆ClN₃O₃ 
• 79008-77-8 2-phenylbenzofuran-5-carbonitrile 
• 871103-28-5 3-chloro-4-(4-chloro-2-methoxyphenoxy)benzonitrile 
• 1306250-23-6 3-cyanobenzyl 2-chloro-4-cyanophenyl ether 

Relevant articles and documents

Visible-light photocatalytic activation of N-chlorosuccinimide by organic dyes for the chlorination of arenes and heteroarenes

A variety of arenes and heteroarenes are chlorinated in moderate to excellent yields using N-chlorosuccinimide (NCS) under visible-light activated conditions. A screening of known organic dye photocatalysts resulted in the identification of methylene green as the most efficient catalyst to use with NCS. According to mechanistic studies described within, the reaction is speculated to proceed via a single electron oxidation of NCS utilizing methylene green under visible-light photoredox pathway. The photo-oxidation of NCS amplifies the electrophilicity of the chlorine atom of the NCS, thus leading to enhanced reactivity as a chlorinating reagent with aromatic substrates.

TRICYCLIC PIPERIDINE COMPOUNDS

The present invention relates to compounds of the formula (I), wherein R, R1a, R1b, R2, R3, and X are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), to methods for the preparation of such compounds of formula (I), and especially to their use as TPH modulators.

An adamantyl-substituted retinoid-derived molecule that inhibits cancer cell growth and angiogenesis by inducing apoptosis and binds to small heterodimer partner nuclear receptor: Effects of modifying its carboxylate group on apoptosis, proliferation, and

Apoptotic and antiproliferative activities of small heterodimer partner (SHP) nuclear receptor ligand (E)-4-[3′-(1-adamantyl)-4′- hydroxyphenyl]-3-chlorocinnamic acid (3-Cl-AHPC), which was derived from 6-[3′-(1-adamantyl)-4′-hydroxyphenyl]-2-naphthalenec