23155-00-2

Basic information

• Product Name: rac trans-4-Hydroxy Glyburide
• Synonyms: 4-trans-Hydroxycyclohexyl Glyburide;5-Chloro-N-[2-[4-[[[[(trans-4-hydroxycyclohexyl)aMino]carbonyl]aMino]sulfonyl]phenyl]ethyl]-2-MethoxybenzaMide;N-[4-[β-(2-Methoxy-5-chlorobenzaMido)ethyl] benzenesulfonyl]-N'-(trans-4-hydroxycyclohexyl)urea;trans-1-[[p-[2-(5-Chloro-o-anisaMido)ethyl]phenyl] sulfonyl]-3-(4-hydroxycyclohexyl)urea;trans-4-Hydroxyglyburide
• CAS NO: 23155-00-2
• Molecular Formula: C₂₃H₂₈ClN₃O₆S
• Molecular Weight: 510.00292
• Product Categories: Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Sulfur & Selenium Compounds;Chiral Reagents, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds
• Mol File: 23155-00-2.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
• Stability: Hygroscopic and Moisture Sensitive
• CAS DataBase Reference: rac trans-4-Hydroxy Glyburide(CAS DataBase Reference)
• NIST Chemistry Reference: rac trans-4-Hydroxy Glyburide(23155-00-2)
• EPA Substance Registry System: rac trans-4-Hydroxy Glyburide(23155-00-2)

Safety Data

• Hazardous Substances Data: 23155-00-2(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

rac trans-4-Hydroxy Glyburide is a metabolite of Glyburide which is used as an antidiabetic.

Upstream product

• 27489-62-9 trans-4-hydroxycyclohexylamine 
• 14511-59-2 Ethyl 4-<2-(5-chloro-2-methoxybenzamido)ethyl>benzenesulfonamidecarbamate 
• 16673-34-0 5-chloro-2-methoxy-N-(4-sulfamoylphenethyl)benzamide 
• 6850-65-3 p-hydroxycyclohexylamine 

Relevant articles and documents

Hydroxyl-Substituted sulfonylureas as potent inhibitors of specific [3H]Glyburide binding to rat brain synaptosomes

We are seeking to discover potent CNS-active sulfonylureas with structural features that allow for the formation of several types of prodrugs. We report herein the syntheses of compounds comprising an initial series of hydroxyl-substituted analogues of the potent ATP-sensitive potassium channel blockers glyburide (glibenclamide) and gliquidone. Somewhat unexpectedly, several of the compounds were found to be comparably potent to glyburide as inhibitors of specific [3H]glyburide binding in rat brain preparations.