231607-31-1Relevant articles and documents
Alkylating agents from sugars. Alkyl hexopyranoside derivatives as carrier systems for chlorambucil
Iglesias-Guerra, Fernando,Candela, Jose I.,Bautista, Juan,Alcudia, Felipe,Vega-Perez, Jose M.
, p. 71 - 84 (2007/10/03)
Chlorambucil derivatives involving alkyl 2-aminodeoxy sugars have been synthesized in good yield by coupling the chlorambucil moiety to positions C-2 or C-3 of the sugar, directly or via a spacer. The starting material was easily available from 2-acetamido-2-deoxy-D-glucose. The final compounds were tested for cytotoxicity, and some of those that presented the best results were studied for inhibition of cell proliferation. Copyright (C) 1999 Elsevier Science Ltd.