231617-03-1

Basic information

• Product Name: N-[1-(2,5-dimethoxy-phenyl)-ethyl]-N-(1-phenyl-but-3-enyl)-acetamide
• CAS NO: 231617-03-1
• Molecular Weight: 353.461
• Mol File: 231617-03-1.mol

Chemical Properties

• CAS DataBase Reference: N-[1-(2,5-dimethoxy-phenyl)-ethyl]-N-(1-phenyl-but-3-enyl)-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[1-(2,5-dimethoxy-phenyl)-ethyl]-N-(1-phenyl-but-3-enyl)-acetamide(231617-03-1)
• EPA Substance Registry System: N-[1-(2,5-dimethoxy-phenyl)-ethyl]-N-(1-phenyl-but-3-enyl)-acetamide(231617-03-1)

Safety Data

• Hazardous Substances Data: 231617-03-1(Hazardous Substances Data)

Upstream product

• 108-24-7 acetic anhydride 
• 231616-95-8 <(R)-1-(2,5-dimethoxyphenyl)ethyl><(R)-1-phenylethyl>amine 
• 231616-87-8 (R)-1-(2,5-dimethoxyphenyl)ethylamine 

Downstream Products

• 231617-04-2 (R)-N-acetyl-4-amino-4-phenyl-1-butene 

Relevant articles and documents

Design, synthesis, and optical resolution of a novel non-natural chiral auxiliary, 1-(2,5-dimethoxyphenyl)ethylamine. Application to diastereoselective alkylation of aldimines

A chiral amine; 1-(2,5-dimethoxyphenyl)ethylamine, was found to be an effective chiral auxiliary for the diastereoselective alkylation of its aldimines with alkylmetals. The 1-(2,5-dimethoxyphenyl)ethyl group of the chiral auxiliary could be removed by the acetylation and then oxidation of the resultant alkylated product, accompanying an amino-transfer from the chiral auxiliary to the final product. Racemic 1-(2,5- dimethoxyphenyl)ethylamine could be easily synthesized from 1,4- dimethoxybenzene and resolved by the diastereomeric salt formation with mandelic acid to give both enantiomers in pure forms.