23169-37-1

Usage

Uses

9-(4-Hydroxybutyl)guanine is used in methods for Nucleic Acid sequencing.

InChI:InChI=1/C9H13N5O2/c10-9-12-7-6(8(16)13-9)11-5-14(7)3-1-2-4-15/h5,15H,1-4H2,(H3,10,12,13,16)

Upstream product

• 105797-63-5 Acetic acid 4-[2-amino-6-(2-methoxy-ethoxy)-purin-9-yl]-butyl ester 
• 108437-69-0 4-(2-amino-6-chloropurin-9-yl)butyl acetate 
• 57325-61-8 7-methyl-10-oxo-9,10-dihydropyrimido<1,2-a>purine 
• 73-40-5 2-amino-1,9-dihydro-6H-purin-6-one 
• 151370-30-8 9-[4-(tert-Butyl-diphenyl-silanyloxy)-butyl]-6-chloro-9H-purin-2-ylamine 
• 10310-21-1 2-Amino-6-chloropurin 
• 107124-25-4 3-(4-acetoxybutyl)-7-methyl-10-oxo-9,10-dihydropyrimido<1,2-a>purine 
• 107698-71-5 ethanoic acid-3-(ethanoic acid-butyr-4-yl ester)-5,6,7,9-tetrahydro-5-(1-oxoethyl)-9-oxo-3H-imidazo<1,2-a>purine-6,7-diyl ester 
• 105797-65-7 Acetic acid 4-(2-amino-6-benzyloxy-purin-9-yl)-butyl ester 
• 105797-61-3 9-(4-acetoxybutyl)-6-butoxyguanine 

Relevant academic research and scientific papers

Synthesis and anti-HSV activity of tricyclic penciclovir and hydroxybutylguanine derivatives

A series of tricyclic penciclovir (PCV) and hydroxybutylguanine (HBG) derivatives have been prepared with enhanced lipophilicity following an efficient synthetic route. All the novel tricyclic derivatives were evaluated for inhibitory activity against her

Solid-Liquid Phase Transfer Catalysis II: A Convenient Approach to the Synthesis of ACV, HBG and Related Compounds

When solid-liquid phase transfer catalysis is conducted in the presence of potassium tert-butoxide as base, 18-crown-6 ether or tetraglyme as catalyst, DMF as solvent and at temperature of 0 deg C, the N-alkylation takes place at the N-1 and N-9 in pyrimidine and purine heterocyclic respectively.

THE ALKYLATION OF 2-AMINO-6-CHLOROPURINE WITH ALCOHOLS BY MITSUNOBU REACTION FOR A SYNTHESIS OF CARBOCYCLIC GUANOSINE ANALOGS

Mitsunobu reaction of 2-amino-6-chloropurine with various alcohols which provides a convenient method for a synthesis of carbocyclic or acyclic guanosine analogs is described.

REGIOSELECTIVE ALKYLATION OF 6-(β-METHOXYETHOXY)GUANINE TO GIVE THE 9-ALKYLGUANINE DERIVATIVE

In the presence of lithium hydride 6-(β-methoxyethoxy)guanine reacts regioselectively with 4-bromobutyl acetate to give the 9-alkylguanine derivative.