23175-16-8Relevant academic research and scientific papers
SUBSTITUTED PIPERAZINES AS CB1 ANTAGONISTS
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Page/Page column 164; 164-165, (2009/03/07)
Compounds of Formula (I) or pharmaceutically acceptable salts, solvates, or esters thereof, are useful in treating diseases or conditions mediated by CB1 receptors, such as metabolic syndrome and obesity, neuroinflammatory disorders, cognitive disorders and psychosis, addiction (e.g., smoking cessation), gastrointestinal disorders, and cardiovascular conditions.
Synthesis and pharmacological testing of 1,2,3,4,10,14b-hexahydro-6-methoxy-2-methyldibenzo[c,f]pyrazino[1,2-a]azepin and its enantiomers in comparison with the two antidepressants mianserin and mirtazapine
Wikstr?m, H?kan V.,Mensonides-Harsema, Marguérite M.,Cremers, Thomas I. F. H.,Moltzen, Ejner K.,Arnt, J?rn
, p. 3280 - 3285 (2007/10/03)
The synthesis and resolution of 1,2,3,4,10,14b-hexahydro-6-methoxy-2-methy[dibenzo[c,f]pyrazino [1,2-α]azepin (6-methoxymianserin, 6) are described. Furthermore, the in vitro and in vivo effects of 6 and its enantiomers are presented. 6 displayed high aff
