23184-92-1

Usage

Type of compound

Organic compound

Classification

Amine derivative

Chlorine atom

Attached to a secondary amine group

Methyl group

Attached to a secondary carbon atom

Applications

Intermediate in the production of pharmaceuticals
Intermediate in the production of agrochemicals

Synthesis

Potential use in the synthesis of various nitrogen-containing organic compounds

Handling

Handle with caution due to potential hazards and its role as a reactive intermediate in chemical processes

Upstream product

• 2658-24-4 2,2-dimethylaziridine 
• 102505-61-3 N-(2-chloro-1,1-dimethylethyl)phthalimide 
• 124-68-5 2-Amino-2-methyl-1-propanol 

Downstream Products

• 72622-74-3 (β-amino-isobutyl)-(hydroxy-tert-butyl)-amine 
• 285124-73-4 2-(2-methyl-4-nitrophenylimino)-4,4-dimethyl-1,3-thiazolidine 
• 285124-73-4 2-(2-methyl-4-nitrophenylimino)-4,4-dimethyl-1,3-thiazolidine 

Relevant academic research and scientific papers

Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents

This invention relates to 2-arylimino heterocycles, including 2-arylimino-1,3-thiazolidines, 2-arylimino-2,3,4,5-tetrahydro-1,3-thiazines, 2-arylimino-1,3-thiazolidin-4-ones, 2-arylimino-1,3-thiazolidin-5-ones, and 2-arylimino-1,3-oxazolidines, and their use in modulating progesterone receptor mediated processes, and pharmaceutical compositions for use in such therapies.

Determination des pKa et reaction d'ouverture acide de quelques alkyl-2 et aryl-2 aziridines

Some 2-para substituted aryl aziridines (with pY = CH3O-, CH3-, H-, and Cl-) have been prepared.Their ring opening reaction in acidic medium has been studied and compared with those of two aliphatic aziridines : 2 methyl- and 2,2 dimethyl-aziridine.In aqueous solvent, the addition of HCl, HBr, and HI to the aromatic aziridines leads exclusively to the secondary halogen product, due to the nucleophilic attack on the benzylic carbon.The hydrolysis reaction competes with the addition reaction and is very important for the para methoxy 2-phenyl aziridine.In ethyl alcohol (anhydrous solvent), the hydrohalogenation reaction leads exclusively to halogeno amine with a secondary halogen.The solvolysis reaction, leading to amino-ether, is far less important than in water (excepted for the para methoxy 2-phenyl aziridine).In both solvents, the importance of the solvolysis depends on the HX concentration, as well as the nucleophilic strength of the halogen.The pKa values of these aziridines have been measured, as well as those of 2-phenyl 1-amino 2-ethanol.A linear plot is obtained for the pKa versus ?+p of Brown ; the slopes are respectively -2.8 and 0.Therefore the aromatic aziridines seem to have a behavior similar to that of anilines.