23206-20-4

Usage

Uses

Used in Pharmaceutical Industry:
3-HYDROXYISOINDOLIN-1-ON is used as a key intermediate in the synthesis of isoquinolin-1(2H)-one derivatives, which are important in the development of new drugs. Its chemical properties make it a valuable compound for creating novel pharmaceutical agents with potential therapeutic applications.
Used in Chemical Research:
As a slightly yellow solid, 3-HYDROXYISOINDOLIN-1-ON can be utilized in various chemical research applications, including the study of its reactivity, stability, and potential interactions with other compounds. This research can lead to a better understanding of its properties and potential uses in various industries.

InChI:InChI=1/C9H9NO2/c11-8-5-10-9(12)7-4-2-1-3-6(7)8/h1-4,8,11H,5H2,(H,10,12)

Upstream product

• 623-11-0 1-methyl-4-nitrosobenzene 
• 35690-69-8 3-aminomethyl-phthalide; hydrochloride 
• 856355-27-6 2-(2-amino-1-hydroxy-ethyl)-benzoic acid 
• 90563-80-7 acetamide 
• 164992-12-5 2-Oxiranyl-benzoesaeuremethylester 

Downstream Products

• 491-30-5 1-hydroxyisoquinoline 
• 491-30-5 1-isoquinolone 

Relevant academic research and scientific papers

Transition-metal-catalyzed intramolecular cyclization of amido(hetero)arylboronic acid aldehydes to isoquinolinones and derivatives

We report an innovative and simple three step high yielding synthesis of a library of 14 chiral isoquinolinone and azepinone derivatives with benzyl, pyridyl and thiophene cores starting from amidoarylboronic acid aldehydes. These products have potential for treating neurodegenerative diseases. The key reaction in this synthetic pathway was an efficient metal-catalyzed (with Rh, Cu and Pd catalysts) intramolecular cyclization. A maximum yield of 87% was obtained using a Rh(i) catalyst. This journal is

A new synthetic route to isoquinolin-1(2H)-one derivatives from 3-hydroxyphthalides

A new synthetic route for the conversion of substituted 3-hydroxyphthalides into the corresponding isoquinolin-1(2H)-one was established. This method can be applied to the preparation of isoquinolin-1(2H)-ones with electron-withdrawing groups that are relatively difficult to synthesize by conventional procedures.

1-Ethoxy-3,4-dihydroisoquindines

1-(2-Substituted-hydrazino)-3,4-dihydroisoquinolines, prepared in one process by alkylating the corresponding 3,4-dihydroisocarbostyrils, hydrazinolyzing the resulting 1-alkoxy-3,4-dihydroisoquinolines and condensing the resulting 1-hydrazIno-3,4-dihydroisoquinolines with aldehydes or ketones, and 1,1'-azinobis(1,2,3,4-tetrahydroisoquinolines), prepared by condensing corresponding 1-alkoxy-3,4-dihydroisoquinolines and 1-hydrazino-3,4-dihydroisoquinolines, are useful as antihypertensive agents and/or as antiinflammatory agents.