23208-05-1

Upstream product

• 23208-04-0 1-(2-aminobenzyl)-2-pyrrolecarbonitrile 
• 143879-98-5 11-(di-4-morpholinylphosphinyloxy)-5H-pyrrolo<2,1-c><1,4>benzodiazepine 
• 624-84-0 formic acid hydrazide 
• 143879-96-3 ethyl 1-(2-nitrobenzyl)-2-pyrrolecarboxylate 
• 27046-47-5 1-(2-nitrobenzyl)-2-pyrrolecarbonitrile 
• 22162-52-3 1-(2-nitrobenzyl)-2-pyrrolecarboxaldehyde oxime 
• 143879-97-4 ethyl 1-(2-aminobenzyl)-2-pyrrolecarboxylate 
• 73033-45-1 1-(2-aminobenzyl)-2-pyrrolecarboxylic acid 
• 139308-30-8 2-Pyrrol-1-ylmethyl-benzoyl azide 
• 2199-43-1 ethyl 1H-pyrrole-2-carboxylate 
• 29872-21-7 o-nitrobenzyl iodide 

Relevant academic research and scientific papers

A Convenient Route to Diazepines by Intramolecular Cyclisation of Carbonylazides

The appriopriate substituted carbonylazides I treated with warm acetic acid give the corresponding acetamide IV or the cyclic lactam VI.This is a convenient route to 10,11-Dihydro-5H-pyrrolobenzodiazepin-11-one and 10,11-Dihydro-4H-thieno2,3-

Derivatives of 11-(1-Piperazinyl)-5H-pyrrolobenzodiazepine as Central Nervous System Agents

Four 11-(1-piperazinyl)5H-pyrrolobenzodiazepines were prepared and evaluated as central nervous system agents.All were active psychotropic agents as determined by animal screening tests.The most interesting compound, 11-(1-piperazinyl)-5H-pyrrolobenzodiazepine, showed dual activity as an antidepressant against tetrabenazine depression and as a neuroleptic as measured by protection vs. amphetamine lethality in grouped mice.

5H-Pyrrolo[2,1-c][1,4]benzodiazepine derivatives

This disclosure describes substituted 11-piperazinyl-5H-pyrrolo[2,1-c][1,4]benzodiazepines useful as anti-psychotic or neuroleptic agents.