23211-38-3

Basic information

• Product Name: (Z)-4-(2-bromo-2-nitrovinyl)-1,2-dichlorobenzene
• Synonyms: (Z)-4-(2-bromo-2-nitrovinyl)-1,2-dichlorobenzene
• CAS NO: 23211-38-3
• Molecular Weight: 296.935
• Mol File: 23211-38-3.mol

Chemical Properties

• CAS DataBase Reference: (Z)-4-(2-bromo-2-nitrovinyl)-1,2-dichlorobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-4-(2-bromo-2-nitrovinyl)-1,2-dichlorobenzene(23211-38-3)
• EPA Substance Registry System: (Z)-4-(2-bromo-2-nitrovinyl)-1,2-dichlorobenzene(23211-38-3)

Safety Data

• Hazardous Substances Data: 23211-38-3(Hazardous Substances Data)

Upstream product

• 55446-64-5 1,2-Dichloro-4-(1,2-dibromo-2-nitro-ethyl)-benzene 
• 37630-23-2 1,2-dichloro-4-(2-nitrovinyl)benzene 
• 6287-38-3 3,4-dichlorobenzaldehyde 
• 37630-23-2 (E)-1,2-dichloro-4-(2-nitrovinyl)benzene 

Relevant articles and documents

A Metal-Free Domino Process for Regioselective Synthesis of 1,2,4-Trisubstituted Pyrroles: Application toward the Formal Synthesis of Ningalin B

A new one-pot, transition-metal, acid/base-free domino process is developed for the regioselective synthesis of 1,2,4-trisubstituted pyrroles. The process involves 1,3-dipolar cycloaddition of unsymmetrical azomethine ylide resulting from the thermal C-C bond cleavage of unactivated aziridines with β-bromo-β-nitrostyrene, followed by a cascade of elimination and aromatization reaction sequence to preferentially furnish 1,2,4-trisubstituted pyrroles instead of the expected 1,2,3-trisubstituted pyrroles, in good to excellent yields. Further, the application of the methodology for the formal synthesis of ningalin B is delineated.

Research on antitumor chemotherapy: X. β Nitrostyrene and nitrovinyl derivatives

In previous work, the antitumoral cytotoxicity of β nitrostyrenes obtained by simplification of the aristolochic acid molecule was demonstrated. The effect of modifying the 3 characteristic parts of the β nitrostyrene molecule was then investigated. Results in vitro and in vivo indicate a probable mechanism of action for the β nitrostyrene and nitrovinyl compounds studied, and permit definition of the maximum simplification compatible with retention of biological activity.