23220-67-9

Upstream product

• 110-91-8 morpholine 
• 58243-08-6 (E)-3-ethoxyacrylonitrile 
• 372-09-8 cyanoacetic acid 
• 87429-52-5 (Z)-β-morpholino acrylonitrile 
• 122-51-0 orthoformic acid triethyl ester 
• 871-29-4 trans-β-chloroacrylonitrile 
• 3721-37-7 cis-β-chloroacrylonitrile 

Downstream Products

• 926-61-4 3-oxopropanoic acid 
• 82936-42-3 1-(4-bromophenyl)-1H-1,2,3-triazole-4-carbonitrile 
• 128957-54-0 1-(3-Nitro-phenyl)-1H-[1,2,3]triazole-4-carbonitrile 
• 1196153-97-5 ethyl 7-aminopyrazolo[1,5-a]pyrimidine-3-carboxylate 
• 113967-74-1 5-Amino-2-methylthio-1,2,4-triazolo<1,5-a>pyrimidine 
• 5915-16-2 7-amino-1,2,4-triazolo[1,5-a]pyrimidine 
• 104433-15-0 1-morpholino-2-cyano-3-(2',3'-dichlorophenyl)-4-nitro-but-1-ene 
• 128957-56-2 1-(p-tolyl)-1H-1,2,3-triazole-4-carbonitrile 
• 128957-55-1 1-(3-Chloro-phenyl)-1H-[1,2,3]triazole-4-carbonitrile 
• 82936-41-2 1-(4-nitrophenyl)-1H-1,2,3-triazole-4-carbonitrile 
• 136758-32-2 2-(morpholin-4-yl)-4-(4-nitrophenyl)-5-oxo-4H-indeno<1,2-b>pyran-3-carbonitrile 
• 136758-33-3 2-Morpholin-4-yl-5-oxo-4-(3-trifluoromethyl-phenyl)-4,5-dihydro-indeno[1,2-b]pyran-3-carbonitrile 

Relevant academic research and scientific papers

1,2-DITHIOLANE AND DITHIOL COMPOUNDS USEFUL IN TREATING MUTANT EGFR-MEDIATED DISEASES AND CONDITIONS

Compositions of the invention comprise 1,2-dithiolane, dithiol and related compounds useful as therapeutic agents for the treatment and prevention of diseases and conditions associated with aberrant EGFR activity.

Studies with functionally substituted enamines: Synthesis of new aminoazolo-pyrimidines and -1,2,4-triazines

3-Aminoacrylonitrile derivatives (1d-g) coupled with aromatic and heteroaromatic diazonium salts yielding arylhydrazonals and pyrazolo[5,1-c] triazines. The enaminonitriles 1d-g condensed to form dienes 6a-c on reflux in acetic acid. The latter underwent Diels-Alder type addition to naphthoquinone. Aminopyrazolopyrimidines were obtained from reaction of 1d-g with heteroaromatic aminoazoles. Enaminonitrile 1d formed pyran 21 with benzylidenemalononitrile, and dihydropyrimidine 22 with benzaldehyde and urea.

Arylazide additions to α- and β- aminoacrylonitriles: Synthesis of 5-amino and 4-cyano-1,2,3-triazoles. Kinetic study of the cycloaddition

Arylazides reacted with α-aminoacrylonitriles 1 (captodative olefins) to produce in excellant yields 5-amino-1-aryl-1,2,3-triazoles.HCN was spontaneously eliminated from the corresponding triazoline.Reaction of the same 1,3-dipoles with β-aminoacrylonitri

A One Pot Synthesis of β-Cyanoenamines

Orthoesters, cyanoacetic acid and secondary amines react together, in a one step procedure, to produce β-cyanoenamines.

NUCLEOPHILIC SUBSTITUTION IN β-CHLOROACRYLONITRILES

Previously undescribed polyfunctional unsaturated nitriles were obtained by the action of a series of nucleophiles (secondary amines, acids, inorganic salts) on isomeric cis- and trans-β-chloroacrylonitriles in optimum media.The substitution of chlorine in the isomeric β-chloroacrylonitriles is nonstereoselective.

Method of preparing β-alkoxyacrlonitriles

A process for the preparation of a β-alkoxyacrylonitrile of the formula where R is hydrogen or an alkyl moiety, among others, by contacting a compound of the formula where Me is an alkali metal or alkaline earth metal and α is 1 or 2 respectively, an elevated temperature with a halogen compound of the formula where R' is among others a straight or branched alkyl or alkenyl moiety and Hal represents chlorine, bromine, or iodine. Also disclosed is a process for preparing a 3-amino-acrylonitrile of the formula STR1 where R5 and R6 represent, among others, hydrogen, alkyl or alkenyl by contacting a 3-alkoxyacrylonitrile or a metal salt of 3-hydroxyacrylonitrile with ammonia and/or amine. Also disclosed is a process for the preparation of such 3-aminoacrylonitrile by contacting a 3-alkoxyacrylonitrile of the formula STR2 where R' has the meaning given above and R7 has the same meaning as R stated above with an amine of the formula STR3 wherein R5 and R6 represent among others hydrogen, alkyl or alkenyl. The application further discloses a process for preparing a 3-amino-acrylonitrile of the formula STR4 where R5, R6 and R7 have the above meanings by contacting a compound of the formula EQU1 with an amine. The Application also discloses the preparation of two-cyanovinyl esters by reaction of a cyanovinyl compound of the formula EQU2 with an acid halide or an acid anhydride.