5915-16-2

Usage

Uses

Used in Pharmaceutical Industry:
[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-AMINE is used as a potential therapeutic agent for the development of antiviral and anticancer drugs due to its unique chemical structure and potential biological activity.
Used in Organic Synthesis:
[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-AMINE is used as a building block in organic synthesis for the creation of novel compounds with potential biological activity, contributing to the discovery of new pharmaceuticals and other applications.

InChI:InChI=1/C5H5N5/c6-4-1-2-7-5-8-3-9-10(4)5/h1-3H,6H2

Upstream product

• 65157-84-8 β-piperidinoacrylonitrile 
• 61-82-5 3-amino-1,2,4-triazole 
• 2407-68-3 3-dimethylaminoacrylonitrile 
• 23220-67-9 (E)-β-morpholino acrylonitrile 
• 2032-34-0 3,3-bis(ethyloxy)propanenitrile 

Downstream Products

• 88-06-2 2,4,6-Trichlorophenol 

Relevant academic research and scientific papers

Effective method for the synthesis of azolo[1,5-a]pyrimidin-7-amines

[Figure not available: see fulltext.] Condensation of aminoazoles with (2E)-(3-morpholin-4-yl)acrylonitrile and 3,3-diethoxypropionitrile was used to synthesize a series of azolo[1,5-a]pyrimidin-7-amines. It was established that the reactions with certain aminotriazoles gave mixtures of regioisomers: azolo[1,5-а]pyrimidin-7-amines and azolo[4,3-а]pyrimidin-5-amines.

Synthesis of New [1,2,4]Triazolo[1,5-a]pyrimidine Derivatives: Reactivity of 3-Amino[1,2,4]triazole towards Enaminonitriles and Enaminones

A diversity of new 7-substituted[1,2,4]triazolo[1,5-a]pyrimidine and 6-substituted[1,2,4]triazolo[1,5-a]pyrimidine-7-amine derivatives has been synthesized via reaction of 3-amino-[1,2,4]triazole with enaminonitriles and enaminones. The regio orientation and the structure of the products were confirmed by spectral and analytical data and synthesis via an alternative route. The procedure proved to be simple, efficient, and high yielding, and diversities of [1,2,4]triazolo[1,5-a]pyrimidines were obtained.

NMR determination of the structure of azolopyrimidines produced from reaction of bidentate electrophiles and aminoazoles

A variety of aminoazoles were reacted with bidentate electrophiles producing azolopyrimidines. The regioselectivity of the nucleophilic attack could be defined from the 13C chemical shift of the pyrimidine carbons and through NOE experiments.

FAT ACCUMULATION INHIBITORY AGENTS

Aminopyrimidine derivatives represented by general formula: wherein R1 is a hydrogen atom, an alkyl group, an alkenyl group, etc.; R2 and R3 are a hydrogen atom, a halogen atom, an alkyl group, an alkenyl group, etc.; R5 is a hydrogen atom, an alkyl group, etc.; R6 is a C1 to C12 alkyl group, a C2-C12 alkenyl group, etc.; X is a nitrogen atom, CH, etc., can suppress the accumulation of fat in fat cells and are thus effective for the prophylaxis and treatment of various disorders accompanied by increased adipose tissues.