232275-88-6

Usage

Uses

Used in Organic Synthesis:
(2,6-bis(methoxymethoxy)phenyl)boronic acid is used as a building block for the synthesis of various organic compounds. Its ability to react with diols and other nucleophiles makes it a valuable component in creating complex organic molecules.
Used in Pharmaceutical Synthesis:
In the pharmaceutical industry, (2,6-bis(methoxymethoxy)phenyl)boronic acid is used as a key intermediate in the development of new drugs. Its reactivity and structural features contribute to the creation of potential therapeutic agents.
Used in Materials Science:
(2,6-bis(methoxymethoxy)phenyl)boronic acid is utilized in the field of materials science to develop new materials with specific properties. Its incorporation into material structures can lead to advancements in areas such as polymers, coatings, and composites.
Used as a Reagent in Chemical Reactions:
In the realm of chemical reactions, (2,6-bis(methoxymethoxy)phenyl)boronic acid serves as a reagent, particularly in Suzuki-Miyaura cross-coupling reactions. This reaction is a powerful method for forming carbon-carbon bonds, which is essential in the synthesis of many organic compounds.
Overall, (2,6-bis(methoxymethoxy)phenyl)boronic acid is a multifaceted compound with applications spanning across various industries, highlighting its importance in modern chemical research and development.

Upstream product

• 57234-29-4 1,3-bis(methoxymethyl)resorcinol 
• 121-43-7 Trimethyl borate 
• 108-46-3 recorcinol 

Downstream Products

• 420838-23-9 1-(2,6-bis-methoxymethoxy-phenyl)-naphthalene 
• 420838-26-2 2'-benzyloxymethyl-2,6-bis-methoxymethoxy-biphenyl 
• 173300-94-2 2-(naphthalen-1-yl)benzene-1,3-diol 
• 420838-27-3 2-(naphthalen-1-yl)-1,3-phenylene diacetate 
• 420838-30-8 acetic acid 6-acetoxy-2'-benzyloxymethyl-biphenyl-2-yl ester 
• 1426547-61-6 C₂₂H₂₂O₅ 
• 1426547-52-5 1-(2,6-bis(methoxymethoxy)phenyl)-2-naphthaldehyde 
• 1426547-62-7 C₂₂H₂₄O₅ 
• 1426547-63-8 C₂₃H₂₆O₅ 
• 1426547-34-3 2-(3-(methoxymethyl)-1-methylnaphthalen-2-yl)benzene-1,3-diol 
• 1426547-33-2 2-(2-(methoxymethyl)naphthalen-1-yl)benzene-1,3-diol 

Relevant academic research and scientific papers

Competitive Binding Assay with an Umbelliferone-Based Fluorescent Rexinoid for Retinoid X Receptor Ligand Screening

Ligands for retinoid X receptors (RXRs), "rexinoids", are attracting interest as candidates for therapy of type 2 diabetes and Alzheimer's and Parkinson's diseases. However, current screening methods for rexinoids are slow and require special apparatus or facilities. Here, we created 7-hydroxy-2-oxo-6-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-2H-chromene-3-carboxylic acid (10, CU-6PMN) as a new fluorescent RXR agonist and developed a screening system of rexinoids using 10. Compound 10 was designed based on the fact that umbelliferone emits strong fluorescence in a hydrophilic environment, but the fluorescence intensity decreases in hydrophobic environments such as the interior of proteins. The developed assay using 10 enabled screening of rexinoids to be performed easily within a few hours by monitoring changes of fluorescence intensity with widely available fluorescence microplate readers, without the need for processes such as filtration.

Enantioselective synthesis of multisubstituted biaryl skeleton by chiral phosphoric acid catalyzed desymmetrization/kinetic resolution sequence

Described herein is the enantioselective synthesis of multisubstituted biaryl derivatives by chiral phosphoric acid catalyzed asymmetric bromination. Two asymmetric reactions (desymmetrization and kinetic resolution) proceeded successively to afford chiral biaryls in excellent enantioselectivities (up to 99% ee). Both experimental and computational studies suggested that this excellent selectivity could be achieved via a highly organized hydrogen bond network among a substrate, a catalyst (chiral phosphoric acid), and a brominating reagent (N-bromophthalimide).

Facile and highly enantioselective synthesis of axially chiral biaryls by enzymatic desymmetrization

The axially chiral biaryls 2 were obtained in high enantioselectivity by desymmetrization of the σ-symmetric biaryl diacetates 1 by lipase-catalyzed hydrolysis.

Substituted 3-amino biaryl propionic acids as potent VLA-4 antagonists.

A series of substituted N-(3,5-dichlorobenzenesulfonyl)-(L)-prolyl- and (L)-azetidyl-beta-biaryl beta-alanine derivatives was prepared as selective and potent VLA-4 antagonists. The 2,6-dioxygenated biaryl substitution pattern is important for optimizing potency. Oral bioavailability was variable and may be a result of binding to circulating plasma proteins.