23229-38-1Relevant academic research and scientific papers
Reductive lithiation of 1,3-dimethyl-2-arylimidazolidines
Azzena, Ugo,Dettori, Giovanna,Pisano, Luisa,Siotto, Immacolata
, p. 3177 - 3182 (2007/10/03)
Naphthalene catalyzed lithiation of 1,3-dimethyl-2-phenylimidazolidine led to cleavage of the benzylic carbon-nitrogen bond, with formation of an intermediate dianion. Under similar conditions, 1,3-dimethyl-2-(4-chlorophenyl) imidazolidine underwent regioselective cleavage of the aromatic carbon-chlorine bond, leading to a 4-formylphenyllithium equivalent, whilst 1,3-dimethyl-2-(4- methoxymethylphenyl)imidazolidine underwent regioselective cleavage of the benzylic carbon-oxygen bond, leading to a 4-formylbenzyllithium equivalent.
