23233-43-4

Upstream product

• 105-36-2 ethyl bromoacetate 
• 1220-00-4 1,3-bis(4-chlorophenyl)thiourea 
• 105-39-5 chloroacetic acid ethyl ester 
• 79-08-3 bromoacetic acid 
• 106-47-8 4-chloro-aniline 
• 79-11-8 chloroacetic acid 

Downstream Products

• 1352833-97-6 4-[3-(4-chlorophenyl)-2-(4-chlorophenylimino)-4-oxothiazolidin-5-ylidenemethyl]benzoic acid 
• 1352833-90-9 4-{4-[3-(4-chlorophenyl)-2-(4-chlorophenylimino)-4-oxothiazolidin-5-ylidenemethyl]phenoxymethyl}benzoic acid 
• 1352833-94-3 {4-[3-(4-chlorophenyl)-2-(4-chlorophenylimino)-4-oxothiazolidin-5-ylidenemethyl]phenoxy}acetic acid 
• 1416469-17-4 {4-[3-(4-chlorophenyl)-2-(4-chlorophenylimino)-4-oxothiazolidin-5-ylidenemethyl]-2-methoxyphenoxy}acetic acid 
• 1416469-19-6 {3-[3-(4-chlorophenyl)-2-(4-chlorophenylimino)-4-oxothiazolidin-5-ylidenemethyl]phenoxy}acetic acid 
• 56383-57-4 3-(4-chloro-phenyl)-2-(4-chloro-phenylimino)-6-methylsulfanyl-2,3-dihydro-[1,3]thiazin-4-one 
• 55425-14-4 3-(4-chloro-phenyl)-2-(4-chloro-phenylimino)-1,1-dioxo-1λ⁶-thiazolidin-4-one 

Relevant academic research and scientific papers

Novel non-peptidic small molecule inhibitors of secreted aspartic protease 2 (SAP2) for the treatment of resistant fungal infections

Targeting secreted aspartic protease 2 (SAP2), a kind of virulence factor, represents a new strategy for antifungal drug discovery. In this report, the first-generation of small molecule SAP2 inhibitors was rationally designed and optimized using a structure-based approach. In particular, inhibitor 23h was highly potent and selective and showed good antifungal potency for the treatment of resistant Candida albicans infections.

Synthesis and biological evaluation of 2-arylimino-3-pyridin-thiazolineone derivatives as antibacterial agents

With an intention to find more potent antibacterial agents, four halogen disubstituted thiazolineone derivatives (2a-d), five halogen monosubstituted thiazolineone derivatives (2e-i), and eleven 2-arylimino-3-pyridin-thiazolineone derivatives (2j-t) were

Synthesis of novel 4-thiazolidione derivatives as antibacterial agents against drug-resistant Staphylococcus epidermidis

A series of novel substituted 4-thiazolidione derivatives were designed, synthesized, and evaluated in vitro for their antibacterial activities, in comparison with methicillin and ampicillin. Compounds (7d, 7h-k) exhibit good potency in inhibiting the growth of Staphylococcus epidermidis (MIC: 1.57-3.13 μM). Further antibacterial effects of compounds (7d, 7h-k) were investigated using clinical isolates (methicillin-resistant Staphylococcus epidermidis and methicillin-resistant Staphylococcus aureus), in comparison with methicillin and levofloxacin. Compound 7k showed the most potent antibacterial activities among the synthesized compounds.

Synthesis and biological evaluation of halogenated 2-arylimino-3- arythiazolidine-4-ones containing benzoic acid fragments as antibacterial agents

A series of halogenated 2-arylimino-3-ary-thiazolidine-4-ones containing (5-furan-2-yl)-benzoic acid or (5-thiophene-2-yl)-benzoic acid fragments was synthesized, and evaluated in vitro for their antibacterial activity, antibiofilm activity, erythrocyte h