23244-34-0

Basic information

• Product Name: 5-Ethoxy-3-phenylisoxazole
• Synonyms: 5-Ethoxy-3-phenylisoxazole
• CAS NO: 23244-34-0
• Molecular Formula: C₁₁H₁₁NO₂
• Molecular Weight: 189.21
• Mol File: 23244-34-0.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-Ethoxy-3-phenylisoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Ethoxy-3-phenylisoxazole(23244-34-0)
• EPA Substance Registry System: 5-Ethoxy-3-phenylisoxazole(23244-34-0)

Safety Data

• Hazardous Substances Data: 23244-34-0(Hazardous Substances Data)

Upstream product

• 873-67-6 benzonitrile oxide 
• 60-29-7 diethyl ether 
• 927-80-0 1-ethoxyacetylene 
• 1076-59-1 3-phenyl-4H-isoxazol-5-one 
• 698-16-8 benzohydroximoyl chloride 
• 147726-38-3 (Z)-3-Ethoxy-3-ethylsulfanyl-1-phenyl-propenone 
• 932-90-1 Benzaldoxime 
• 18803-02-6 5-methoxy-3-phenylisoxazole 
• 64-17-5 ethanol 
• 3356-89-6 3-phenyl-5-chloroisoxazole 
• 109506-43-6 5,5-diethoxy-3-phenyl-4,5-dihydro-isoxazole 

Downstream Products

• 27025-98-5 5-ethoxy-3-phenyl-isoxazole-4-carboxylic acid 
• 7713-79-3 3-phenyl-5-isoxazolone 

Relevant articles and documents

General Platform for the Conversion of Isoxazol-5-ones to 3,5-Disubstituted Isoxazoles via Nucleophilic Substitutions and Palladium Catalyzed Cross-Coupling Strategies

A general platform for the conversion of isoxazol-5-ones to 3,5-disubstituted isoxazoles has been developed via a two-step strategy. The first step leads to the formation of 5-(pseudo)halogenated isoxazoles, while in the second, a variety of heteroalkyl-, heteroaryl-, alkyl-, alkenyl-, alkynyl- and aryl-chains can be installed via nucleophilic substitutions or palladium catalyzed cross-coupling reactions.

NUCLEOPHILIC DISPLACEMENT OF THE METHOXY GROUP IN 5-METHOXYISOXAZOLE

The reaction of 5-methoxy-3-phenylisoxazole, 1a, with primary and secondary alcohols in the presence of acids gives 5-alkoxy derivatives 1b-d in almost quantitative yields.