232597-43-2

Usage

Uses

Used in Pharmaceutical Industry:
Tert-butyl 4-benzoylphenylcarbamate is used as a building block in organic synthesis for the production of various pharmaceutical compounds, including anti-inflammatory and analgesic drugs. Its versatility and stability contribute to its value in drug development and research.
Used in Polymer and Coatings Production:
Tert-butyl 4-benzoylphenylcarbamate is used as a photoinitiator in the production of polymers and coatings. Its ability to initiate polymerization reactions makes it a useful component in the manufacturing process of these materials.

Upstream product

• 4248-19-5 tert-butyl carbazate 
• 90-90-4 (4-bromophenyl)(phenyl)methanone 
• 143-66-8 sodium tetraphenyl borate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1137-41-3 (4-aminophenyl)(phenyl)methanone 
• 321527-88-2 tert-Butyl [4-(chlorocarbonyl)phenyl]carbamate 
• 66493-39-8 4-(N-tert-butoxycarbonyl)aminobenzoic acid 
• 98-80-6 phenylboronic acid 

Downstream Products

• 1642593-86-9 N-(tert-butoxycarbonyl)-4-(1-phenylvinyl)aniline 

Relevant academic research and scientific papers

Palladium-catalyzed acylative cross-coupling of amides with diarylborinic acids and sodium tetraarylborates

Abstract A general and efficient acylative Suzuki coupling of active amides with diarylborinic acids has been achieved by using 1 mol% Pd(PCy3)2Cl2/0.6 mol% PCy3 as catalyst system taking advantage of modifiable reactivities of acyl-nitrogen bonds of amides. Both electronic and steric influences from either aryl or acyl counterparts on the coupling proved to be negligible or small. A variety of aryl ketones including sterically hindered ones could be synthesized by the coupling of diarylborinic acids in good to excellent yields. Sodium tetraarylborates could also be used as high atom-economy aryl source in the palladium-catalyzed cross-coupling with active amides.

Acylative Suzuki coupling of amides: Acyl-nitrogen activation via synergy of independently modifiable activating groups

A highly efficient palladium-catalyzed acylative cross-coupling of carboxylic amides with arylboronic acids has been achieved via synergistic activation of the Cacyl-N bond by independently modifiable activating groups. Coupling of amides features not only good functional group tolerance but also modifiable reactivities to overcome steric hindrance. This journal is

Direct C-H trifluoromethylation of di- and trisubstituted alkenes by photoredox catalysis

Background: Trifluoromethylated alkene scaffolds are known as useful structural motifs in pharmaceuticals and agrochemicals as well as functional organic materials. But reported synthetic methods usually require multiple synthetic steps and/or exhibit lim

Installation of protected ammonia equivalents onto aromatic & heteroaromatic rings in water enabled by micellar catalysis

A single set of conditions consisting of a palladium catalyst, a commercially available ligand, and a base, allow for several types of C-N bond constructions to be conducted in water with the aid of a commercially available "designer" surfactant (TPGS-750-M). Products containing a protected NH2 group in the form of a carbamate, sulfonamide, or urea can be fashioned starting with aryl or heteroaryl bromides, iodides, and in some cases, chlorides, as substrates. Reaction temperatures are in the range of room temperature to, at most, 50 °C, and result in essentially full conversion and good isolated yields.

Pd-catalyzed amidation of aryl(Het) halides with tert-butyl carbamate

Pd-catalyzed cross-coupling reaction of tert-butyl carbamate with various aryl(Het) halides with Cs2CO3 as base in 1,4-dioxane as solvent was investigated, which resulted in the formation of the desired compounds in moderate to excellent yields.