23282-99-7

Upstream product

• 622-78-6 Benzyl isothiocyanate 
• 3290-99-1 4-methoxybenzoic acid hydrazide 
• 335217-54-4 1-(4-methoxyphenyl)carbonyl-4-benzyl-3-thiosemicarbaside 
• 96989-50-3 di-2-pyridyl thionocarbonate 
• 123-11-5 4-methoxy-benzaldehyde 
• 100-46-9 benzylamine 
• 7701-10-2 4-methoxy-benzaldehyde 4-benzyl-thiosemicarbazone 

Relevant academic research and scientific papers

Design and Synthesis of 1,3,4-Thiadiazole Derivatives as Novel Anticancer and Antitubercular Agents

A series of novel 5-phenyl-substituted 1,3,4-thiadiazole-2-amines were designed, synthesized, and screened for their antitumor and antitubercular activities. The target compounds were synthesized starting from isocyanates and acid hydrazides by convention

Regioselective synthesis of 2-amino-substituted 1,3,4-oxadiazole and 1,3,4-thiadiazole derivatives via reagent-based cyclization of thiosemicarbazide intermediate

A regioselective, reagent-based method for the cyclization reaction of 2-amino-1,3,4-oxadiazole and 2-amino-1,3,4-thiadiazole core skeletons is described. The thiosemicarbazide intermediate 3 was reacted with EDC·HCl in DMSO or p-TsCl, triethylamine in N-

Versatile strategies for the solid phase synthesis of small heterocyclic scaffolds: [1,3,4]-Thiadiazoles and [1,3,4]-oxadiazoles

New robust protocols for the solid phase synthesis of 5-alkylthio-, 5-alkyl/aryl-, and 5-acylamino-2-alkylamino-[1,3,4]-thiadiazoles are described based on a common resin bound thiosemicarbazide. A protocol for the solid phase synthesis of 2-alkyl/aryl-amino-5-alkylamino-[1,3,4]-oxadiazoles from a resin bound semicarbazide is likewise reported. The protocols have been verified by the preparation of four small libraries that all gave products in good to excellent yields and purity.