23285-17-8

Usage

Uses

Used in Pharmaceutical Synthesis:
2,3,5,6,7,8-hexahydro-1,4-benzodithiine is used as a key intermediate in the synthesis of various pharmaceuticals for its potential role in the development of new drugs. Its unique structure allows for the creation of novel compounds with therapeutic properties.
Used in Agrochemical Synthesis:
In the agrochemical industry, 2,3,5,6,7,8-hexahydro-1,4-benzodithiine serves as a crucial building block for the synthesis of new agricultural products, contributing to the development of innovative solutions for crop protection and enhancement.
Used in Fragrance Industry:
2,3,5,6,7,8-hexahydro-1,4-benzodithiine is utilized as a fragrance ingredient in perfumes and personal care products due to its strong and distinctive odor, adding depth and complexity to scent compositions.
However, it is essential to handle 2,3,5,6,7,8-hexahydro-1,4-benzodithiine with care, as it can pose hazards if not properly managed, emphasizing the need for safety precautions in its application and synthesis processes.

Upstream product

• 177-16-2 1,4-dithiaspiro[4.5]decane 
• 108-94-1 cyclohexanone 
• 540-63-6 ethane-1,2-dithiol 
• 533-60-8 cyclohexanone-2-ol 
• 59780-98-2 6-hydroxy-1,4-dithiaspiro<4.5>decane 
• 27694-08-2 6-oxospiro 

Downstream Products

• 27694-08-2 6-oxospiro 

Relevant academic research and scientific papers

Rapid method for the ring expansion of 1,3-dithiolanes and 1,3-dithianes with tert-rutyl hypochlorite

A new method for the ring expansion of 1,3-dithiolanes and 1,3-dithianes to dihydro-1,4-dithiins and dihydro-1,4-dithiepines, respectively, using lert-butyl hypochlorite at room temperature is described. The salient features of the protocol include mild r

A one-pot synthesis of 1,4-dithiins and 1,4-benzodithiins from ketones using the recyclable reagent 1,1′-(ethane-1,2-diyl)dipyridinium bistribromide (EDPBT)

A novel access to 1,4-dithiins and 1,4-benzodithiins from the corresponding ketones in one-pot using the recyclable reagent, 1,1′-(ethane-1,2-diyl)dipyridinium bistribromide (EDPBT) is described. This method is mild, simple, environmentally benign and is

A first example using o-iodoxybenzoic acid (IBX) in combination with tetraethylammonium bromide (TEAB) for ring expansion of 1,3-dithiolanes and 1,3-dithianes

A novel one-pot procedure for the synthesis of dihydro-1,4-dithiins and dihydro-1,4-dithiepines from the corresponding 1,3-dithiolanes and 1,3-dithianes using o-iodoxybenzoic acid (IBX) in combination with tetraethylammonium bromide (TEAB) is described. T

Stereoselective azide introduction during 1,2-sulfur migration in α-hydroxyalkyldithioacetals

A series α-hydroxyalkyldithiolanes were reacted with a mixture of triphenylphosphine, diethyl azodicarboxylate and hydrazoic acid to give 2-azido-l,4-dithianes stereoselectively. Reduction of the azido group to an amine resulted in racemisation.

SYNTHESIS OF SULFUR-CONTAINING HETEROCYCLES BY THERMOLYSIS OF α-ALKYLTHIO-N-AZIRIDINYLIMINES

Thermolysis of α-alkylthio substituted N-aziridinylimines in refluxing toluene gave various structurally different sulfur-containing heterocycles in high yields.

A Facile One-pot Preparation Of 2,3-Dihydro-1,4-benzodithiins And 2,3-Dihydro-1,4-Benzoxathiins

2,3-Dihydro-1,4-benzoditiines and 2,3-dihydro-1,4-benzoxathiines were prepared in good yields by a one-pot procedure from the reaction of cyclohexanone derivatives with ethane-1,2-dithiol or 2-mercaptoethanol using N-bromosuccinimide in dichloromethane at

TELLURIUM TETRACHLORIDE AS A MILD DEPROTECTION REAGENT FOR ACETALS AND THIOACETALS

On treatment with tellurium tetrachloride in dichloromethane at room temperature, acetals and thioacetals are easily cleaved to regenerate original carbonyl compounds in good yields.

Ring Expansion Reaction of 1,3-Dithiolanes and 1,3-Oxathiolanes Using Tellurium Tetrachloride

On treatment with tellurium tetrachloride in dichloromethane at room temperature, 1,3-dithiolanes and 1,3-oxathiolanes undergo smooth ring expansion to give dihydro-1,4-dithiin and dihydro-1,4-oxathiin derivatives respectively in good to moderate yields.

A Convenient Method for the Preparation of Bicyclic Dihydro-1,4-dioxins, Dihydro-1,4-oxathiins, Dihydro-1,4-dithiins and Related Compounds

Acid catalysed reactions of cyclic α-hydroxy ketones with ethylene glycol, 2-mercaptoethanol and 1,2-ethanedithiol furnished in most cases the corresponding dihydro-1,4-dioxin, dihydro-1,4-oxathiin and dihydro-1,4-dithiin derivatives, respectively, in high yields.Similar reactions of 2-hydroxycyclooctanone and 2-hydroxycyclododecanone with 1,3-propanediol gave the corresponding bicyclic dihydro-1,4-dioxepins as sole products.From 2-hydroxycyclohexanone and 1,3-propanedithiol the corresponding bicyclic dihydro-1,4-dithiepin was obtained.In some cases the reaction gave rise to mixtures of isomeric products.A general mechanism for the reaction is proposed.