23291-98-7

Usage

Structure

1H-Indene derivative with a propanoic acid substitution at the 5-position and a 2,3-dihydroconfiguration

Appearance

White to off-white crystalline powder

Solubility

Soluble in organic solvents

Uses

Building block for organic synthesis and pharmaceutical research, used in the synthesis of various compounds

Stability

2,3-Dihydromodification adds stability, making it a versatile starting material for chemical reactions.

Upstream product

• 56635-88-2 3-(5-Indanyl)-prop-2-ensaeure 
• 23291-97-6 indan-5-ylmethyl-malonic acid diethyl ester 
• 30084-91-4 indan-5-carbaldehyde 
• 501649-52-1 5-(bromomethyl)-2,3-dihydro-1H-indene 
• 113364-54-8 1-(2-indan-5-yl-2-oxo-ethyl)-pyridinium; iodide 
• 35288-49-4 p-phenylenediacrylic diacid dichloride 
• 86031-43-8 methyl 5-indanecarboxylate 
• 65898-38-6 indan-5-carboxylic acid 
• 51632-06-5 (2,3-dihydro-1H-inden-5-yl)methanol 
• 5312-03-8 dimethyl 3,3'-(1,4-phenylene)dipropanoate 
• 7549-44-2 dimethyl-1,4-phenylenediacrylate 
• 4251-21-2 3,3'-(1,4-phenylene)dipropanoic acid 
• 4228-10-8 1-indan-5-yl-ethanone 
• 496-11-7 INDANE 

Downstream Products

• 14927-64-1 3,5,6,7-tetrahydro-2H-s-indacen-1-one 
• 14927-65-2 3,6,7,8-tetrahydro-2H-as-indacen-1-one 
• 495-52-3 s-hydrindacene 
• 78112-58-0 C₄₂H₃₂O₂ 
• 78112-57-9 C₄₂H₃₂ 
• 78112-50-2 5,6,7,8-Tetraphenyl-1,2,3,9-tetrahydro-cyclopenta[b]fluorene 
• 78240-56-9 C₃₈H₂₆ 
• 78112-52-4 5,8-Diethyl-6,7-diphenyl-1,2,3,9-tetrahydro-cyclopenta[b]fluorene 
• 78112-51-3 5,8-Dimethyl-6,7-diphenyl-1,2,3,9-tetrahydro-cyclopenta[b]fluorene 

Relevant academic research and scientific papers

N-phenpropylcuclopentyl-substituted glutaramide derivatives as inhibitors of neutral endopeptidase

The invention relates to compounds of formula (I) for treating for example sexual dysfunction, wherein R1 is optionally substituted C1-6alkyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, hydrogen, C1-6alkoxy, —NR2 R3 or —NR4SO2R5; X is the linkage —(CH2)n— or —(CH2)q—O— (wherein Y is attached to the oxygen); wherein one or more hydrogen atoms in linkage X may be replaced independently by C1-4alkoxy; hydroxy; hydroxy(C1-3alkyl); C3-7cycloalkyl; carbocyclyl; heterocyclyl; or by C1-4alkyl optionally substituted by one or more fluoro or phenyl groups; n is 3, 4, 5, 6 or 7; and q is 2, 3, 4, 5 or 6; and Y is phenyl or pyridyl, each of which may be substituted; or two R8 groups on adjacent carbon atoms together with the interconnecting carbon atoms may form a fused optionally substituted 5- or 6-membered carbocyclic or heterocyclyic ring.

Aromatic Spiranes, XIV: Syntheses of 2,2'-Spirobi-(s-hydrindacene) and its precursors

The title compound 35 was prepared by catalytic reduction of the diones 29a and 11a. 29a was synthesized by systematic anellation of fivemembered rings to the positions 5,6 and 5',6', resp., of 2,2'-spirobiindane.The preparation of 11a was achieved by Friedel-Crafts cyclisation of bis-(5-indanylmethyl)-malonic acid. s-Hydrindacene-1-one 5a was prepared as a precursor for the synthesis of 11a (see forthcoming publication) and its derivates as models for corresponding anellation and substitution reactions. - Keywords: s-Hydrindacene-1-one and derivates; Mono- and bisanellation; 2,2'-Spirobiindane; 1H-nmr spectra

Tricyclic aromatic ketones by cycliacylation of carboxylic acid derivatives of indan, tetralin, and benzosuberane

The synthesis of a homologous series of new carboxylic acids substituted in the α-position of indan, tetralin, and benzosuberane is accomplished using an efficient general procedure.Cycliacylation of these acids and their corresponding β-isomers produces a complete series of tricyclic aromatic ketones.